JIGAR KASALLIKLARI VA BACHADON MIOMASI TERAPIYASIDA FITOKIMYOVIY KOMPONENTLARNING O‘RNI VA ULARNING ORGANIK KIMYOVIY TASNIFI
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https://doi.org/10.5281/zenodo.20454346;
Silybum marianum, Rhodiola quadrifida, Chelidonium majus, silibinin diastereomerlari, flavonolignanlar, feniletanoid glikozidlar, xelidonin alkaloidi, estrogen metabolizmi, gepatoprotektor, bachadon miomasi, fitokimyoviy tahlil, stereokimyo.Abstrak
Ushbu maqolada jigar patologiyalari va gormonga bog‘liq xavfsiz o‘sma — bachadon miomasini fitoterapiya yordamida muolaja qilishning o‘zaro biologik va kimyoviy bog‘liqliklari o‘rganilgan. Maqolada asosiy e’tibor Silybum marianum, Rhodiola quadrifida va Chelidonium majus kabi dorivor o‘simliklarning tarkibidagi faol organik birikmalar — flavonolignanlar, glikozidlar hamda alkaloidlarning kimyoviy tuzilishi, stereokimyosi, izomeriyasi va ta’sir mexanizmlariga qaratilgan.Iqtiboslar
Organik kimyo va farmakognoziya yo‘nalishidagi maqolalar uchun xalqaro APA / Scopus standartiga mos keladigan adabiyotlar ro‘yxati: AbouZid, S. F., & Ahmed, H. S. (2021). Phytochemical and pharmacological review of Silybum marianum (L.) Gaertn. (Milk Thistle). Journal of Medicinal Plants Research, 15(4), 154-168. (Silimarin kompleksi va uning gepatoprotektorlik xossasi haqida).
ren, V., & Walterová, D. (2005). Silybin and silymarin—new effects and applications. Biomedical Papers of the Medical Faculty of the University Palacký in Olomouc, 149(1), 29-41. (Silibinin A va B diastereomerlarining kimyoviy tuzilishi bo‘yicha fundamental ish).
Panossian, A., & Wikman, G. (2010). Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress-Protective Activity. Pharmaceuticals, 3(1), 188-224. (Rhodiola turlaridagi salidrozid glikozidining gormonal ta'sir mexanizmi).
Colombo, M. L., & Bosisio, E. (1996). Pharmacological activities of Chelidonium majus L. (Papaveraceae). Phytotherapy Research, 10(2), 123-132. (Xelidonin alkaloidining o‘smalarga qarshi sitostatik xususiyati).
Federici, E., & Giorgi, G. (2018). Estrogen metabolism and the role of the liver in gynecological pathologies: A biochemical approach. European Journal of Endocrinology, 179(3), R115-R128. (Jigar va bachadon miomasi o‘rtasidagi estrogenik bog‘liqlik).
Murch, S. J., & Saxena, P. K. (2006). Phytochemical diversity and stereochemistry of bioactive polyphenols in medicinal plants. Trends in Plant Science, 11(8), 387-394. (Polifenollar va ularning radikallarni bog‘lash kimyoviy reaksiyalari).
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