MICROBIOLOGICAL FACTORS AFFECTING THE DEVELOPMENT OF BRONCHIAL ASTHMA IN CHILDREN
DOI:
https://doi.org/10.5281/zenodo.20339297Keywords:
bronchial asthma, prevention, morbidity, children, allergy.Abstract
Bronchial asthma is one of the most common chronic non-communicable diseases in childhood, affecting 5–10% of school-aged children and adolescents, as well as 1–18% of the population in different countries. There are significant global differences in the prevalence of asthma symptoms among children, with variations between countries reaching up to 13-fold. According to estimates by the World Health Organization, 339 million people worldwide suffer from asthma, and 461,000 deaths caused by this disease have been recorded. According to data from the Centers for Disease Control and Prevention, the overall economic burden of bronchial asthma in school-aged children amounts to approximately 2 billion dollars per year. These costs include direct medical expenses such as medications, hospitalization, outpatient treatment, and emergency medical care, as well as reduced parental productivity due to children missing school because of bronchial asthma exacerbations.References
Di Filippo, P.; Giannini, C.; Attanasi, M.; Dodi, G.; Scaparrotta, A.; Petrosino, M.I.; Di Pillo, S.; Chiarelli, F. Pulmonary outcomes in children born extremely and very preterm at 11 years of age. Front. Pediatr. 2021, 9.
Franck, U.; Weller, A.; Röder, S.W.; Herberth, G.; Junge, K.M.; Kohajda, T.; von Bergen, 63M.; Rolle-Kampczyk, U.; Diez, U.; Borte, M.; et al. Prenatal VOC exposure and redecoration are related to wheezing in early infancy. Environ. Int. 2014, 73, 393–401.
Sonnenschein-van der Voort, A.M.M.; Arends, L.R.; de Jongste, J.C.; Annesi-Maesano, I.; Arshad, S.H.; Barros, H.; Basterrechea, M.; Bisgaard, H.; Chatzi, L.; Corpeleijn, E.; et al. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. J. Allergy Clin. Immunol. 2014, 133, 1317–1329.
Crump, C.; Winkleby, M.A.; Sundquist, J.; Sundquist, K. Risk of asthma in young adults who were born preterm: A Swedish national cohort study. Pediatrics 2011, 127, 913–e920.
Baraldi, E.; Filippone, M. Chronic lung disease after premature birth. N. Engl. J. Med. 2007, 357, 1946–1955.
García-Serna, A.M.; Martín-Orozco, E.; Hernández-Caselles, T.; Morales, E. Prenatal and perinatal environmental influences shaping the neonatal immune system: A focus on asthma and allergy origins. Int. J. Environ. Res. Public Health 2021, 18, 3962.
Van Berkel, A.C.; den Dekker, H.T.; Jaddoe, V.W.V.; Reiss, I.K.; Gaillard, R.; Hofman, A.; de Jongste, J.C.; Duijts, L. Mode of delivery and childhood fractional exhaled nitric oxide, interrupter resistance and asthma: The generation R study. Pediatr. Allergy Immunol. 2015, 26, 330–336.
Wypych-Ślusarska, A.; Niewiadomska, E.; Oleksiuk, K.; Krupa-Kotara, K.; Głogowska-Ligus, J.; Słowiński, J. Caesarean delivery and risk of childhood asthma development: Meta-analysis. Adv. Dermatology Allergol.2021,38, 819–826.
Thysen, A.H.; Larsen, J.M.; Rasmussen, M.A.; Stokholm, J.; Bønnelykke, K.; Bisgaard, H.; Brix, S. Prelabor cesarean section bypasses natural immune cell maturation. J. Allergy Clin. Immunol. 2015, 136, 1123–1125.e6.
Lynch, S.V.; Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 2016, 375, 2369–2379.
Abrahamsson, T.R.; Jakobsson, H.E.; Andersson, A.F.; Björkstén, B.; Engstrand, L.; Jenmalm, M.C. Low gut microbiota diversity in early infancy precedes asthma at school age. Clin. Exp. Allergy 2014,44, 842–850.
Yuan, C.; Gaskins, A.J.; Blaine, A.I.; Zhang, C.; Gillman, M.W.; Missmer, S.A.; Field, A.E.; Chavarro, J.E. Association between cesarean birth and risk of obesity in offspring in childhood, adolescence, and early adulthood. JAMA Pediatr. 2016, e162385.
Liu, Y.; Qin, S.; Song, Y.; Feng, Y.; Lv, N.; Xue, Y.; Liu, F.; Wang, S.; Zhu, B.; Ma, J.; et al. The perturbation of infant gut microbiota caused by cesarean delivery is partially restored by exclusive breastfeeding. Front. Microbiol. 2019,10, 598.
Thavagnanam, S.; Fleming, J.; Bromley, A.; Shields, M.D.; Cardwell, C.R. A meta-analysis of the association between caesarean section and childhood asthma. Clin. Exp. Allergy 2008, 38, 629–633.
Eidelman, A.I.; Schanler, R.J.; Johnston, M.; Landers, S.; Noble, L.; Szucs, K.; Viehmann, L. Breastfeeding and the use of human milk. Pediatrics 2012, 129.
Lodge, C.; Tan, D.; Lau, M.; Dai, X.; Tham, R.; Lowe, A.; Bowatte, G.; Allen, K.; Dharmage, S. Breastfeeding and asthma and allergies: A systematic review and meta-analysis. Acta Paediatr. 2015, 104, 38–53.
Frank, N.M.; Lynch, K.F.; Uusitalo, U.; Yang, J.; Lönnrot, M.; Virtanen, S.M.; Hyöty, H.; Norris, J.M. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children. BMC Pediatr. 2019.
Kuniyoshi, Y.; Tsujimoto, Y.; Banno, M.; Taito, S.; Ariie, T. Neonatal jaundice, phototherapy and childhood allergic diseases: Allergy Immunol. 2021, 32, 690–701.
Han, X.; Krempski, J.W.; Nadeau, K. Advances and novel developments in mechanisms of allergic inflammation. Allergy 2020,75, 3100–3111.
Budden, K.F.; Shukla, S.D.; Rehman, S.F.; Bowerman, K.L.; Keely, S.; Hugenholtz, P.; Armstrong-James, D.P.H.; Adcock, I.M.; Chotirmall, S.H.; Chung, K.F.; et al. Functional effects of the microbiota in chronic respiratory disease. Lancet Respir. Med.2019, 7, 907–920.
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