NEONATAL SEPSISDA IL-6/IL-10 NISBATIGA ASOSLANGAN IMMUN FENOTIPLAR VA ULARNING KLINIK-PROGNOSTIK AHAMIYATI
Vol. 4 No. 64 (2026) 96-97
Abstract
Neonatal sepsisda immun javob bir yo‘nalishda kechmaydi: proinflamator va antiinflamator mexanizmlar bir vaqtning o‘zida turli nisbatlarda faollashadi. Tadqiqotda IL-6, IL-8 va IL-10 ning ketma-ket dinamikasi hamda IL-6/IL-10 nisbatiga asoslangan immun fenotiplar baholandi. Aralash fenotip 62,5%, ustun antiinflamator fenotip 27,5% va ustun proinflamator fenotip 10,0% holatda aniqlandi. Yetti sutkada IL-6 va IL-8 darajasi mos ravishda 90,4% va 89,9% ga, IL-10 esa 71,0% ga kamaydi. Immun fenotiplar bo‘yicha klinik natijalardagi farqlar statistik ahamiyatga yetmagan bo‘lsa-da, antiinflamator profil reanimatsiyada uzoqroq qolish tendensiyasi bilan kechdi. Natijalar sitokinlarni nSOFA, SRB va prokalsitonin bilan kompleks baholash zarurligini ko‘rsatadi.
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References
Hotchkiss R.S., Monneret G., Payen D. Immunosuppression in sepsis. Lancet Infect Dis. 2013;13(3):260-268.
Hotchkiss R.S. et al. Sepsis and septic shock. Nat Rev Dis Primers. 2016;2:16045.
Fleiss N. et al. Neonatal SOFA score and mortality in late-onset sepsis. Pediatr Res. 2020;88(4):622-627.
Weiss S.L. et al. Surviving Sepsis Campaign pediatric guidelines. Pediatr Crit Care Med. 2020;21(2):e52-e106.
Cohen-Wolkowiez M. et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009;28(12):1052-1056.
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2026-08-07
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Muxtorov, J. (2026). NEONATAL SEPSISDA IL-6/IL-10 NISBATIGA ASOSLANGAN IMMUN FENOTIPLAR VA ULARNING KLINIK-PROGNOSTIK AHAMIYATI. Young Scientists, 4(64), 96-97. https://doi.org/10.5281/zenodo.21837274
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