FERMENTLARGA SEZGIR MAQSADLI DORI YETKAZUVCHI GIDROGELLARNI SANOAT MIQYOSIDA STERILLASH JARAYONLARINING VALIDATSIYASI

Authors

  • Yusupova Karina O’razboyevna Sanoat farmatsiyasi fakulteti, sanoat farmatsiyasi yo‘nalishi 309-A guruh talabasi Author

DOI:

https://doi.org/10.5281/zenodo.21448928

Keywords:

Validatsiya, Gidrogellar, Sterillash, Gamma nurlanish, Avtoklavlash, GMP standartlari.

Abstract

Tezisda matriks metalloproteinaza fermentiga sezgir intellektual gidrogellarni sterillash jarayonlarining validatsiyasi o'rganilgan. GMP va FDA talablariga muvofiq, avtoklavlash (121 daraja) va gamma nurlanish (25 kGy) usullarining polimer matritsasi destruksiyasiga ta'siri qiyosiy baholandi. Termik avtoklavlash peptid aloqalarining muddatidan oldin gidrolizlanishiga olib keldi. Muqobil ravishda validatsiyalangan past haroratli radiatsion sterillash uslubi dori shaklining sterillik kafolati indeksini (SAL) 10/-6 gacha ta'minlash bilan birga polimer strukturasining biologik faolligini 98 foiz darajada saqlab qoldi.

References

Asoev, M., & Karimov, X. (2025). Smart polimer dori shakllarini sanoatda sterilizatsiya qilish muammolar. O'zbekiston Farmatsevtik Bulleteni, 2, 14-22.

Bawa, P., et al. (2024). Sterilization of stimuli-responsive hydrogels: A review.

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Published

2026-07-20

Issue

Vol. 4 No. 63 (2026)

Section

Articles

License

Copyright (c) 2026 Innovative Academy RSC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Yusupova, K. (2026). FERMENTLARGA SEZGIR MAQSADLI DORI YETKAZUVCHI GIDROGELLARNI SANOAT MIQYOSIDA STERILLASH JARAYONLARINING VALIDATSIYASI. Young Scientists, 4(63), 64-65. https://doi.org/10.5281/zenodo.21448928
Innovative Academy RSC
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