TUBERKULYOZ KASALLIGIDA MYCOBACTERIUM TUBERCULOSIS-NING IMMUN EVASIYA MEXANIZMLARI VA ZAMONAVIY TERAPEVTIK MAQSADLAR
Keywords:
Mycobacterium tuberculosis, immun evasiya, fagosoma, MDR-TB, bedaquiline, granuloma dinamikasi.Abstract
Tuberkulyoz patogenezida Mycobacterium tuberculosis-ning makrofaglar ichida saqlanib qolish mexanizmlari hali to'liq o'rganilmagan. Ushbu tezisda fagosoma-lizosom qo'shilishini bloklash, reaktiv kislorod turlarini neytrallash va T-limfotsit apoptozini modulyatsiya qilish orqali sodir bo'luvchi immun evasiya yo'llari tahlil qilinadi. Bedaquiline va delamanid preparatlarining ATP-sintaza va metanogenez yo'llariga selektiv ta'siri asosida MDR-TB davolashda yangi terapevtik oyna mavjudligi ko'rsatiladi.
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