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NITENPYRAM TAHLILI UCHUN KOMBINATSIYALASHGAN XROMATOGRAFIK–SPEKTROFOTOMETRIK USULLARNI ISHLAB CHIQISH VA ULARNING ANALITIK SAMARADORLIGINI QIYOSIY BAHOLASH

Jild 4 son 48 (2026) 109-115

2026-05-20 Maqolalar CC BY 4.0 Open Access

Mualliflar

  • Mirzaalimov Sirajidin Talibjanovich Qo‘qon universiteti Andijon filiali, Biologik kimyo va farmatsevtika kafedrasi katta o‘qituvchisi

Annotatsiya

Ushbu tadqiqotda nitenpyramning veterinariya preparatlaridagi miqdorini aniqlash uchun kombinatsiyalashgan xromatografik va spektrofotometrik usullar ishlab chiqildi hamda qiyosiy baholandi. HPLC-UV, HPLC-DAD, UPLC-MS/MS, TLC-densitometriya va SPE-UV usullari ICH Q2(R1) talablari asosida validatsiya qilindi. UPLC-MS/MS usuli eng yuqori sezuvchanlikni namoyish etdi (LOD = 0.0008 µg/mL), HPLC-DAD esa yuqori aniqlik va optimal narx-samaradorlik ko‘rsatkichlari bilan ajralib turdi. Barcha usullarda tiklanish 97.8–100.1% va RSD qiymatlari 0.45–2.87% oralig‘ida qayd etildi. Ishlab chiqilgan usullar Capstar® va Vetri-Kem® preparatlari tahlilida yuqori ishonchlilik va takroriylikni ko‘rsatdi. Olingan natijalar ushbu usullarning veterinariya farmatsevtikasi va pestitsid nazoratida samarali qo‘llanishini tasdiqlaydi.

Kalit soʻzlar:

nitenpyram neonikotinoid insektitsidlar HPLC-UV HPLC-DAD UPLC-MS/MS TLC-densitometriya analitik validatsiya veterinariya preparatlari.

Iqtiboslar

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    Mirzaalimov, S. (2026). NITENPYRAM TAHLILI UCHUN KOMBINATSIYALASHGAN XROMATOGRAFIK–SPEKTROFOTOMETRIK USULLARNI ISHLAB CHIQISH VA ULARNING ANALITIK SAMARADORLIGINI QIYOSIY BAHOLASH. Yosh Olimlar, 4(48), 109-115. https://www.in-academy.uz/index.php/YO/article/view/49557
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