SURUNKALI BUYRAK KASALLIGI RIVOJLANISHINING PATOGENETIK JIHATLARI
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https://doi.org/10.5281/zenodo.20284853;
surunkali buyrak kasalligi, patogenez, RAAS, fibroz, TGF-β1, oksidativ stress, genetika.Abstrak
Surunkali buyrak kasalligi (SBK) buyrak funksiyasining asta-sekin pasayishi va buyrak to‘qimalarida qaytmas strukturaviy o‘zgarishlarning rivojlanishi bilan tavsiflanadigan murakkab multifaktorial patologik jarayon hisoblanadi [1,2]. So‘nggi yillarda SBK dunyo miqyosida keng tarqalgan surunkali kasalliklardan biri sifatida e’tirof etilib, uning terminal bosqichlari nogironlik, yurak-qon tomir asoratlari va o‘lim xavfining sezilarli oshishi bilan kechishi aniqlangan [3]. Kasallik patogenezida gemodinamik buzilishlar, yallig‘lanish jarayonlari, oksidativ stress, fibroz, metabolik o‘zgarishlar va genetik moyillik asosiy o‘rin tutadi.Iqtiboslar
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Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389(10075):1238–1252.
Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–272.
Remuzzi G, Benigni A, Remuzzi A. Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest. 2006;116(2):288–296.
Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, et al. TGF-β signaling in vascular fibrosis. Cardiovasc Res. 2007;74(2):196–206.
Daenen K, Andries A, Mekahli D, Van Schepdael A, Jouret F, Bammens B. Oxidative stress in chronic kidney disease. Pediatr Nephrol. 2019;34(6):975–991.
Kazancioğlu R. Risk factors for chronic kidney disease: an update. Kidney Int Suppl. 2013;3(4):368–371.
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