SHIFF ASOSLARI SINTEZINING ZAMONAVIY USULLARI VA ULARNING FARMATSEVTIK ISTIQBOLLARI
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Shiff asoslari, iminlar, kondensatsiya reaksiyasi, farmatsevtik kimyo, antibakterial faollik, organik sintez.Abstrak
Farmatsevtik kimyoda biologik faol birikmalarni sintez qilish va ularning farmakologik xususiyatlarini o‘rganish dolzarb ilmiy yo‘nalishlardan biri hisoblanadi. Shiff asoslari (Schiff bases) tarkibida azometin (-CH=N-) guruhi tutuvchi organik birikmalar bo‘lib, ular farmatsevtik kimyo, koordinatsion kimyo va tibbiyotda keng qo‘llaniladi. Ushbu birikmalar antibakterial, antifungal, antivirus, antioksidant va o‘smaga qarshi faollikka ega bo‘lishi mumkinligi sababli ilmiy tadqiqotlarda alohida qiziqish uyg‘otmoqda.
Iqtiboslar
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da Silva C.M., da Silva D.L., Modolo L.V., et al. Schiff bases: A short review of their antimicrobial activities. Journal of Advanced Research. 2011;2(1):1–8.
Patai S. The Chemistry of the Carbon–Nitrogen Double Bond. John Wiley & Sons; 1970.
Gupta K.C., Sutar A.K. Catalytic activities of Schiff base transition metal complexes. Coordination Chemistry Reviews. 2008;252:1420–1450.
Singh K., Barwa M.S., Tyagi P. Schiff bases and their metal complexes: a review. European Journal of Medicinal Chemistry.
Silverstein R.M., Webster F.X., Kiemle D.J. Spectrometric Identification of Organic Compounds. 8th ed. Wiley.
March J. Advanced Organic Chemistry. 7th ed. Wiley.
Patrick G.L. An Introduction to Medicinal Chemistry. Oxford University Press.
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