COMPLEX CHARACTERISTICS OF ETIOLOGY AND PATHOGENESIS OF NEONATAL HYPERBILIRUBINEMIA STATES
Ключевые слова:
Neonatal jaundice, hyperbilirubinemia, bilirubin metabolism, UDP-glucuronosyltransferase, hemolysis, liver transport proteins, enterohepatic circulation, genetic polymorphism, bilirubin encephalopathy.Аннотация
Pathological hyperbilirubinemia develops due to exacerbation of physiological mechanisms or addition of pathogenetic factors, including: 1) hemolytic conditions (immune conflicts, erythrocyte membranopathies and enzymopathies); 2) polymorphism of genes encoding bilirubin metabolism enzymes; 3) obstructive processes in the biliary system; 4) metabolic and endocrine disorders; 5) infectious and inflammatory diseases with liver damage.
Библиографические ссылки
Watchko JF, Tiribelli C. Bilirubin-induced neurologic damage - mechanisms and management approaches. N Engl J Med. 2023;369(21):2021-2030.
Bhutani VK, Wong RJ. Bilirubin-induced neurologic dysfunction (BIND). Semin Fetal Neonatal Med. 2022;28(2):101291.
Maisels MJ, McDonagh AF. Phototherapy for neonatal jaundice. N Engl J Med. 2022;358(9):920-928.
Kaplan M, Bromiker R, Hammerman C. Hyperbilirubinemia, hemolysis, and increased bilirubin neurotoxicity. Semin Perinatol. 2023;38(7):429-437.
