2-TIP QANDLI DIABET PATOGENEZIDA AUTOFAGIYA JARAYONINING ROLI VA INTERVAL OCHLIKNING BIOKIMYOVIY KORREKSIYASI
;
T2DM, autofagiya, interval ochlik, mTOR/AMPK balansi, insulin sensitivity, amiloid agregatlar, beta-hujayralar regeneratsiyasi.Abstrak
Dunyo miqyosida 2-tip qandli diabet (T2DM) patogenezida hujayra darajasidagi metabolik disfunksiya asosiy omil bo‘lib qolmoqda. Ushbu maqolada surunkali giperinsulinemiya sharoitida mTOR signal yo‘lining o‘ta faollashuvi natijasida autofagiya jarayonining bloklanishi tahlil qilinadi. Tadqiqot interval ochlik (16:8) rejimi orqali AMPK oqsilini faollashtirish va "metabolik kalit" mexanizmini ishga tushirish imkoniyatlarini ko‘rib chiqadi. Ma’lumotlar shuni ko‘rsatadiki, 16–18 soatlik ochlik beta-hujayralardagi amiloid agregatlarini parchalash orqali insulin rezistentligini biokimyoviy korreksiya qiladi. Olingan natijalar T2DM nazoratida farmakologik yuklamani kamaytirish va kasallik remissiyasiga erishishda sitotsentrik yondashuvning afzalliklarini asoslab beradi
Iqtiboslar
Levine, B., & Kroemer, G. (2019). Autophagy in health and disease. Cell.
Mattson, M. P., et al. (2018). Intermittent fasting and metabolic health. Nature Reviews Neuroscience.
Ohsumi, Y. (2014). Historical landmarks of autophagy research. Cell Research.
International Diabetes Federation. (2024). IDF Diabetes Atlas.
Yoshii, S. R., & Mizushima, N. (2017). Monitoring and Measuring Autophagy. Int. J. Mol. Sci.
Longo, V. D., & Panda, S. (2022). Fasting and Time-Restricted Feeding. Cell Metabolism.
Azizova, F. X. (2022). Biokimyo asoslari. Toshkent.
Zhang, S. X., et al. (2023). Autophagy in pancreatic beta-cells. J. Mol. Cell Biol.
Hardie, D. G. (2020). AMPK: an energy-sensing switch. Nature Reviews.
Saxton, R. A., & Sabatini, D. M. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell.
##submission.downloads##
Nashr qilingan
Nashr
Bo'lim
Iqtibos keltirish tartibi
