THE ROLE OF AUTOPHAGY IN THE PATHOGENESIS OF TYPE 2 DIABETES AND BIOCHEMICAL CORRECTION OF INTERVAL FASTING
Keywords:
T2DM, autophagy, intermittent fasting, mTOR/AMPK balance, insulin sensitivity, amyloid aggregates, beta-cell regeneration.Abstract
Metabolic dysfunction at the cellular level remains a key factor in the pathogenesis of type 2 diabetes mellitus (T2DM) worldwide. This article analyzes the blockade of the autophagy process as a result of excessive activation of the mTOR signaling pathway in conditions of chronic hyperinsulinemia. The study examines the possibilities of activating the AMPK protein and triggering the "metabolic switch" mechanism through the intermittent fasting (16:8) regime. The data show that 16–18 h of fasting biochemically corrects insulin resistance by breaking down amyloid aggregates in beta cells. The results obtained justify the advantages of a cytocentric approach in reducing the pharmacological burden in the control of T2DM and achieving disease remission.
References
Levine, B., & Kroemer, G. (2019). Autophagy in health and disease. Cell.
Mattson, M. P., et al. (2018). Intermittent fasting and metabolic health. Nature Reviews Neuroscience.
Ohsumi, Y. (2014). Historical landmarks of autophagy research. Cell Research.
International Diabetes Federation. (2024). IDF Diabetes Atlas.
Yoshii, S. R., & Mizushima, N. (2017). Monitoring and Measuring Autophagy. Int. J. Mol. Sci.
Longo, V. D., & Panda, S. (2022). Fasting and Time-Restricted Feeding. Cell Metabolism.
Azizova, F. X. (2022). Biokimyo asoslari. Toshkent.
Zhang, S. X., et al. (2023). Autophagy in pancreatic beta-cells. J. Mol. Cell Biol.
Hardie, D. G. (2020). AMPK: an energy-sensing switch. Nature Reviews.
Saxton, R. A., & Sabatini, D. M. (2017). mTOR Signaling in Growth, Metabolism, and Disease. Cell.
Downloads
Published
Issue
Section
How to Cite
