THE IMPACT OF VAGINAL MICROBIOTA DYSBIOSIS ON THE PATHOGENESIS OF INFERTILITY AND IVF (IN VITRO FERTILIZATION) OUTCOMES
DOI:
https://doi.org/10.5281/zenodo.20133754Keywords:
Vaginal microbiota, dysbiosis, infertility, IVF (In Vitro Fertilization), Lactobacillus, embryo implantation, reproductive health, bacterial vaginosis.Abstract
This study analyzes the role of vaginal microbiota in the pathogenesis of female infertility and its impact on the success of assisted reproductive technologies (ART/IVF). A comprehensive review of clinical data from the last decade reveals that a depletion of Lactobacillus species (notably L. crispatus) and the presence of dysbiosis trigger an increase in pro-inflammatory cytokines (IL-1β, TNF-α). This inflammatory environment impairs endometrial receptivity and hinders embryo implantation. Evidence suggests that clinical pregnancy rates in women with dysbiosis are 1.5–2 times lower than those with normocenosis, with a significantly higher risk of early pregnancy loss. The study concludes that molecular-genetic screening (PCR, 16S rRNA) of the vaginal ecosystem is a high-value diagnostic tool for predicting IVF success. Furthermore, pre-IVF correction of the microbiota using probiotics and targeted therapy represents a promising strategy for improving reproductive outcomes.
References
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