VAGINAL MIKROBIOTA DISBIOZINING BEPUSHTLIK PATOGENEZI VA EKO (EKU) NATIJALARIGA TA’SIRI
;
https://doi.org/10.5281/zenodo.20133754;
Vaginal mikrobiota, disbioz, bepushtlik, EKO (EKU), Lactobacillus, embrion implantatsiyasi, reproduktiv salomatlik, bakterial vaginoz.Abstrak
Ushbu tadqiqot qin mikrobiotasining ayollar bepushtligi rivojlanishi va yordamchi reproduktiv texnologiyalar (EKO/IVF) samaradorligiga ta’sirini tahlil qiladi. Oxirgi 10 yillikdagi ilmiy ma’lumotlar tahlili shuni ko‘rsatadiki, Lactobacillus turlarining (ayniqsa, L. crispatus) kamayishi va dispioz holatlari mahalliy yallig‘lanish sitokinlari (IL-1β, TNF-α) darajasini oshirib, endometrial retseptivlikni pasaytiradi. Aniqlanishicha, dispiozli ayollarda EKO protokollaridan keyingi homiladorlik ko‘rsatkichi normotsenozga nisbatan 1,5–2 baravar past bo‘lib, erta muddatdagi yo‘qotishlar xavfi yuqori. Tadqiqot xulosasiga ko‘ra, EKOdan avval mikrobiotani molekulyar-genetik (PZR, 16S rRNA) usullarda skrining qilish va aniqlangan buzilishlarni probiotiklar yordamida korreksiya qilish reproduktiv natijalarni yaxshilashda muhim diagnostik va terapevtik ahamiyatga ega
Iqtiboslar
Koedooder, R., Singer, M., Casulli, S., et al. (2019). The vaginal microbiome as a predictor for outcome of in vitro fertilization (IVF): a systematic review and meta-analysis. Scientific Reports, 9(1), 1-13. https://doi.org/10.1038/s41598-019-51151-z
Haahr, T., Jensen, J. S., Thomsen, L., et al. (2016). Abnormal vaginal microbiota may be associated with poor reproductive outcomes: a prospective study in IVF patients. Human Reproduction, 31(4), 795-803. https://doi.org/10.1093/humrep/dew026
Greenbaum, S., Greenbaum, R., Moran-Gilad, J., & Amit, A. (2019). The vaginal and uterine microbiome in human reproduction. Fertility and Sterility, 111(2), 218-225. https://doi.org/10.1016/j.fertnstert.2018.11.044
Verstraelen, H., Vicariotto, F., Diez, S. T., et al. (2020). Probiotics for the treatment of bacterial vaginosis: A revision of the evidence and perspectives. Expert Opinion on Biological Therapy, 20(10), 1-12.
Singer, M., Koedooder, R., Casulli, S., et al. (2022). Impact of the endometrial and vaginal microbiome on IVF outcomes: A systematic review and meta-analysis. Journal of Clinical Medicine, 11(17), 5123. https://doi.org/10.3390/jcm11175123
Schoenmakers, S., Steegers-Theunissen, R., & Faas, M. (2021). The role of the microbiome in human reproduction and pregnancy. Best Practice & Research Clinical Obstetrics & Gynaecology, 72, 1-15. https://doi.org/10.1016/j.bpobgyn.2021.03.005
Ravel, J., Gajer, P., Abdo, Z., et al. (2011/Updated 2021). Vaginal microbiome of reproductive-age women. Proceedings of the National Academy of Sciences (PNAS), 108(Supplement 1), 4680-4687.
Witkin, S. S. (2015). The vaginal microbiome, sexually transmitted infections and increased protection against HIV. Antiviral Therapy, 20(6), 179-182. (Reproduktiv immunologiya bo'yicha tahrirlangan qismlari bilan).
##submission.downloads##
Nashr qilingan
Nashr
Bo'lim
Iqtibos keltirish tartibi
