СОВРЕМЕННЫЕ ПОДХОДЫ К ЛЕЧЕНИЮ ЗАБОЛЕВАНИЯ ГЕПАТИТОМ С
Ключевые слова:
Гепатит, генотип, вирус, печень, HCV.Аннотация
В данной статье освещается значение инфекции вируса гепатита C (HCV) для глобального здоровья, его генотипы, пути передачи и современные подходы к методам лечения. В статье подробно анализируются эпидемиология инфекции HCV, структура вириона и генома, а также отрицательное влияние вируса на функцию печени. В частности, обсуждается эффективность терапии прямого действия противовирусными средствами (DAA), их влияние на различные генотипы и преимущества по сравнению с интерфероновой терапией. Обоснована необходимость скрининга, диагностики, профилактики и постоянного мониторинга на пути достижения целей, установленных ВОЗ по полной ликвидации HCV. Также особое внимание уделяется вопросам резистентности, связанной с терапией DAA, риску гепатоцеллюлярной карциномы (HCC) и мониторингу с использованием неинвазивных биомаркеров
Библиографические ссылки
Basit H, Tyagi I, Koirala J. Hepatitis C. 2023 Mar 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 28613647.
Brunetto MR, Bonino F. The Natural History of Hepatitis C Virus Infection and Disease in the Era of Curative Therapy with Direct-Acting Antivirals. Viruses. 2025 Feb 26;17(3):319. doi: 10.3390/v17030319. PMID: 40143248; PMCID: PMC11945315.
Fahnøe U, Madsen LW, Christensen PB, Sølund CS, Mollerup S, Pinholt M, Weis N, Øvrehus A, Bukh J. Effect of direct-acting antivirals on the titers of human pegivirus 1 during treatment of chronic hepatitis C patients. Microbiol Spectr. 2024 Sep 3;12(9):e0064124. doi: 10.1128/spectrum.00641-24. Epub 2024 Jul 25. PMID: 39051781; PMCID: PMC11370240.
Fasano M, Ieva F, Ciarallo M, Caccianotti B, Santantonio TA. Acute Hepatitis C: Current Status and Future Perspectives. Viruses. 2024 Nov 6;16(11):1739. doi: 10.3390/v16111739. PMID: 39599853; PMCID: PMC11599108.
Ferreira J, Sheflin-Findling S. Update on Pediatric Hepatitis C Infection. Curr Gastroenterol Rep. 2025 Feb 28;27(1):18. doi: 10.1007/s11894-024-00955-3. PMID: 40019674; PMCID: PMC11870864.
Garbuglia AR, Pauciullo S, Zulian V, Del Porto P. Update on Hepatitis C Vaccine: Results and Challenges. Viruses. 2024 Aug 21;16(8):1337. doi: 10.3390/v16081337. PMID: 39205311; PMCID: PMC11359353.
Goh L, Hardikar W. Hepatitis C in Children-An Asia-Pacific Concise Perspective. Pathogens. 2024 Oct 1;13(10):860. doi: 10.3390/pathogens13100860. PMID: 39452731; PMCID: PMC11510634.
Hartley C, Van T, Karnsakul W. Direct-Acting Antiviral Agents in Prevention of Maternal-Fetal Transmission of Hepatitis C Virus in Pregnancy. Pathogens. 2024 Jun 16;13(6):508. doi: 10.3390/pathogens13060508. PMID: 38921805; PMCID: PMC11206561.
Inzaule S, Easterbrook P, Latona A, Ford NP, Irving W, Matthews PC, Vitoria M, Duncombe C, Giron A, McCluskey S, Lesi O, Tchamgoue S, Halford R, Adda D, Thomson E, Dusheiko G, Jordan MR. Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis. Clin Infect Dis. 2024 Dec 17;79(6):1437-1446. doi: 10.1093/cid/ciae431. PMID: 39361017; PMCID: PMC11650865.
Kaewdech A, Charatcharoenwitthaya P, Piratvisuth T. Asian Perspective on Hepatitis B Virus and Hepatitis C Virus Elimination. Viruses. 2024 Dec 29;17(1):34. doi: 10.3390/v17010034. PMID: 39861823; PMCID: PMC11768638.
Le DHH, Kanokudom S, Nguyen HM, Yorsaeng R, Honsawek S, Vongpunsawad S, Poovorawan Y. Hepatitis C Virus-Core Antigen: Implications in Diagnostic, Treatment Monitoring and Clinical Outcomes. Viruses. 2024 Nov 29;16(12):1863. doi: 10.3390/v16121863. PMID: 39772172; PMCID: PMC11680303.
Martinello M, Matthews GV. Reinfection After Hepatitis C Virus Treatment-Keep Testing, Keep Treating. JAMA Netw Open. 2024 Aug 1;7(8):e2430290. doi: 10.1001/jamanetworkopen.2024.30290. PMID: 39186277.
Mbisa JL, Lapp Z, Bibby DF, Phillips LT, Manso CF, Packer S, Simmons R, Harris K, Mohan J, Chinnappan L, Leitner T, Bradshaw D. Identification of 2 Novel Subtypes of Hepatitis C Virus Genotype 8 and a Potential New Genotype Successfully Treated With Direct Acting Antivirals. J Infect Dis. 2024 Dec 16;230(6):e1254-e1262. doi: 10.1093/infdis/jiae253. PMID: 38717937; PMCID: PMC11646602.
Ocampo F, Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P; RV254/SEARCH 010 Study Team. Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. AIDS Res Ther. 2025 Feb 19;22(1):20. doi: 10.1186/s12981-025-00707-x. PMID: 39972347; PMCID: PMC11841302.
Pol S, Thompson AJ, Collins M, Venier E, Cotte L, Laguno Centeno M, Mera J, Reiberger T, Burroughs M, Semizarov DG, Iacob AM, Welhaven A, Fredrick LM, Doyle JS. Effectiveness and safety of glecaprevir/pibrentasvir for 8 weeks in the treatment of patients with acute hepatitis C: A single-arm retrospective study. Hepatology. 2025 Mar 1;81(3):1006-1018. doi: 10.1097/HEP.0000000000000923. Epub 2024 May 20. PMID: 38768260; PMCID: PMC11825497.
Ratiu IA, Mihaescu A, Olariu N, Ratiu CA, Cristian BG, Ratiu A, Indries M, Fratila S, Dejeu D, Teusdea A, Ganea M, Moisa C, Marc L. Hepatitis C Virus Infection in Hemodialysis Patients in the Era of Direct-Acting Antiviral Treatment: Observational Study and Narrative Review. Medicina (Kaunas). 2024 Dec 21;60(12):2093. doi: 10.3390/medicina60122093. PMID: 39768975; PMCID: PMC11678887.
Sacdalan C, Pinyakorn S, Paudel M, Wansom T, Poltubtim N, Sriplienchan S, Phanuphak N, Paul R, Hsu D, Colby D, Trautmann L, Spudich S, Chan P; RV254/SEARCH 010 Study Team. Neuropsychiatric and laboratory outcomes of hepatitis C treatment in an early-treated HIV cohort in Thailand. AIDS Res Ther. 2025 Feb 19;22(1):20. doi: 10.1186/s12981-025-00707-x. PMID: 39972347; PMCID: PMC11841302.
Simão M, Gonçalves C. Hepatitis C Virus Infection in Europe. Pathogens. 2024 Sep 28;13(10):841. doi: 10.3390/pathogens13100841. PMID: 39452713; PMCID: PMC11510056.
Smirne C, Crobu MG, Landi I, Vercellino N, Apostolo D, Pinato DJ, Vincenzi F, Minisini R, Tonello S, D'Onghia D, Ottobrelli A, Martini S, Bracco C, Fenoglio LM, Campanini M, Berton AM, Ciancio A, Pirisi M. Chronic Hepatitis C Infection Treated with Direct-Acting Antiviral Agents and Occurrence/Recurrence of Hepatocellular Carcinoma: Does It Still Matter? Viruses. 2024 Dec 10;16(12):1899. doi: 10.3390/v16121899. PMID: 39772206; PMCID: PMC11680226.
Zhao L, Hall M, Giridhar P, Ghafari M, Kemp S, Chai H, Klenerman P, Barnes E, Ansari MA, Lythgoe K. Genetically distinct within-host subpopulations of hepatitis C virus persist after Direct-Acting Antiviral treatment failure. PLoS Pathog. 2025 Apr 1;21(4):e1012959. doi: 10.1371/journal.ppat.1012959. PMID: 40168433; PMCID: PMC11981120.
Zhu X, Jia L, Yue M, Zhang A, Xia X, Yu R, Chen H, Huang P. DAA treatment for HCV reduce risk of hepatocellular carcinoma: a 10-years follow-up study based on Chinese patients with hepatitis C. Sci Rep. 2024 Oct 10;14(1):23760. doi: 10.1038/s41598-024-75280-w. PMID: 39390065; PMCID: PMC11467374.
Загрузки
Опубликован
Выпуск
Раздел
Как цитировать
