IMATINIB ESSINAT SUBSTANSIYASINI SINTEZI, IDENTIFIKATSIYASI VA O’TKIR ZAHARLILIGINI O’RGANISH
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Saraton, tirozinkinaza, zaharlilik, spektrofotometr, xromatografiya,imatinib essinat.Abstrak
Saraton kasalligi dunyo miqyosida jadal suratlarda rivojlanib borayotgan kasallik hisoblanib,o’lim ko’rsatkichi bo’yicha dunyoda ikkinchi o’rinni egallaydi. Jahon Sogʼliqni saqlash tashkilotining ma’lumotlariga koʼra, 2020-yilda 18.1 mln, 2023-yilda 19.5 mln yangi kasallanish holatlari aniqlangan. 2040-yilga kelib yangi kasallanish koʼrsatkichi 50.7% ga oʼsib 29.4 mln nafarga yetishi bashorat qilinmoqda. Soʼnggi 20 yil ichida dunyo boʼylab saraton kasalligini davolashda qo’llash uchun mo’ljallangan 237 ta yangi faol substansiya sintezlandi. Ularning 115 nafari soʼnggi besh yilllikda sintezlandi. Saraton kasalligini davolashda tirozinkinaza ingibitorlari muhim ahamiyatga ega. Saraton kasalligini davolashda ishlatiladigan dori vositalari zaharli ta’sirga ega moddalar bo’lib, bunday farmakologik ta’sirga ega kam zaharli vositalarni sintezlash va ularning o’tkir zaharliligini baholash va LD50 dozani aniqlash muhim ahamiyatga kasb etadi.
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