STUDY OF SYNTHESIS, IDENTIFICATION AND ACUTE TOXICITY OF IMATINIB AESCINATE SUBSTANCE
Keywords:
Cancer, tyrosine kinase, toxicity, spectrophotometr, chromatography, imatinib aescinate.Abstract
Cancer is a rapidly developing disease worldwide, and it ranks second in the world in terms of mortality rate. According to the World Health Organization, in 2020, 18.1 million, and in 2023, 19.5 million new cases of the disease were detected. By 2040, the number of new cases is predicted to increase by 50.7% to 29.4 million. Over the past 20 years, 237 new active substances designed for use in the treatment of cancer have been synthesized worldwide. 115 of them were synthesized in the last five years. Tyrosine kinase inhibitors are important in the treatment of cancer. Medicines used in the treatment of cancer are substances with toxic effects, and it is important to synthesize less toxic agents with such pharmacological effects and evaluate their acute toxicity and determine the LD50 dose.
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