MODELLASHTIRILGAN HAYVONLARDA INSULIN REZISTENLIGI KELIB CHIQISHINING FIZIOLOGIK XUSUSIYATLARI
Keywords:
insulin rezistenligi, laboratoriya hayvonlari, fiziologik mexanizmlar, yallig‘lanish, glyukoza utilizatsiyasi, lipogenez, adiponektin, oksidlovchi stress.Abstract
Ushbu maqolada laboratoriya sharoitida insulin rezistenligi (IR) modellashtirilgan hayvonlarda kuzatiladigan asosiy fiziologik mexanizmlar batafsil tahlil qilinadi. Skelet mushaklari, jigar, yog‘ to‘qimasi, pankreas, gipotalamus-gipofizar-adrenal tizim hamda immun-endokrin tizimidagi o‘zgarishlarning IR rivojlanishidagi patofiziologik ahamiyati ko‘rib chiqiladi va ilmiy tadqiqotlar asosida yoritiladi.
References
Samuel, V. T., & Shulman, G. I. (2016). The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux. The Journal of Clinical Investigation, 126(1), 12–22.
Petersen, M. C., & Shulman, G. I. (2018). Mechanisms of insulin action and insulin resistance. Physiological Reviews, 98(4), 2133–2223.
Czech, M. P. (2017). Insulin action and resistance in obesity and type 2 diabetes. Nature Medicine, 23(7), 804–814.
Reaven, G. M. (2005). Insulin resistance, cardiovascular disease, and the metabolic syndrome. Diabetes Care, 28(4), 895–900.
Hotamisligil, G. S. (2017). Inflammation, metaflammation and immunometabolic disorders. Nature, 542(7640), 177–185.
