IN VIVO PHARMACODYNAMIC EVALUATION OF GLYCYRRHETINIC ACID DERIVATIVES: AN IMRAD-BASED COMPARATIVE ANALYSIS OF SIX ORIGINAL STUDIES FROM HIGH-IMPACT JOURNALS
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Historically, a large portion of the glycyrrhetinic acid literature has focused on synthesis and in vitro screening.Аннотация
While many publications emphasize in vitro cytotoxicity, the translational value of GA derivatives depends heavily on their in vivo pharmacodynamic behavior, including the ability to suppress tumor growth, reduce inflammatory edema, modulate cytokine networks, inhibit metastasis, and improve histopathological outcomes in animal models. The aim of the present IMRAD-based review article was to analyze the in vivo pharmacodynamic direction of glycyrrhetinic acid derivative research through six original experimental studies published in reputable journals with real and verifiable DOI numbers. The selected papers covered several pharmacodynamic domains: antitumor activity in xenograft and ascites models, anti-inflammatory activity in topical and systemic inflammation models, anti-metastatic action, and dual anti-inflammatory/antimicrobial or antitumor properties
Библиографические ссылки
Huang M. et al. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A. Bioorganic Chemistry. 2020;103:104187. DOI: 10.1016/j.bioorg.2020.104187.
Yang Y. et al. Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives. Bioorganic Chemistry. 2020;101:103985. DOI: 10.1016/j.bioorg.2020.103985.
Markov A.V. et al. Novel Glycyrrhetinic Acid Derivative Soloxolone Methyl Inhibits the Inflammatory Response and Tumor Growth in vivo. Molecular Biology. 2018;52(2):306–313. DOI: 10.7868/S0026898418020143.
Tu B. et al. Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity. Bioorganic Chemistry. 2022;122:105714. DOI: 10.1016/j.bioorg.2022.105714.
Salomatina O.V. et al. Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo. International Journal of Molecular Sciences. 2022;23(11):6214. DOI: 10.3390/ijms23116214.
Markov A.V. et al. Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo. Pharmaceuticals. 2022;15(5):603. DOI: 10.3390/ph15050603.
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