IN VIVO PHARMACODYNAMIC EVALUATION OF GLYCYRRHETINIC ACID DERIVATIVES: AN IMRAD-BASED COMPARATIVE ANALYSIS OF SIX ORIGINAL STUDIES FROM HIGH-IMPACT JOURNALS
Keywords:
Historically, a large portion of the glycyrrhetinic acid literature has focused on synthesis and in vitro screening.Abstract
While many publications emphasize in vitro cytotoxicity, the translational value of GA derivatives depends heavily on their in vivo pharmacodynamic behavior, including the ability to suppress tumor growth, reduce inflammatory edema, modulate cytokine networks, inhibit metastasis, and improve histopathological outcomes in animal models. The aim of the present IMRAD-based review article was to analyze the in vivo pharmacodynamic direction of glycyrrhetinic acid derivative research through six original experimental studies published in reputable journals with real and verifiable DOI numbers. The selected papers covered several pharmacodynamic domains: antitumor activity in xenograft and ascites models, anti-inflammatory activity in topical and systemic inflammation models, anti-metastatic action, and dual anti-inflammatory/antimicrobial or antitumor properties
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