BIOLOGY-DRIVEN MANAGEMENT OF LOCALLY ADVANCED STAGE III GASTRIC CANCER: A SITUATIONAL ANALYSIS AND PRACTICAL TREATMENT ALGORITHM
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Gastric cancer; locally advanced gastric cancer; stage III; FLOT; XELOX; laparoscopic gastrectomy; neoadjuvant chemotherapy; MSI-H; HER2; CLDN18.2; precision oncology.Abstrak
Gastric cancer remains one of the most clinically important malignancies worldwide, particularly in countries where population-based endoscopic screening is not routinely implemented and a considerable proportion of patients present with locally advanced disease. Stage III gastric cancer is traditionally regarded as a surgical disease requiring radical gastrectomy and D2 lymphadenectomy. However, modern evidence clearly demonstrates that surgery alone is insufficient for many patients, and multimodal treatment has become the cornerstone of curative-intent management.
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