DETERMINATION OF TECHNOLOGICAL PROPERTIES OF DRY EXTRACT OF RUBIA TINCTORUM L.

Abstrak

This study investigated the technological properties of a compressible mass intended for tablets used in the treatment of urolithiasis. Dry extracts of Rubia tinctorum (Bo‘yoqdor ro‘yan) was selected as active substance. Initial tests revealed unsatisfactory technological indicators: uneven particle size distribution, poor flowability, high compressibility coefficient, and excessive residual moisture. Application of the wet granulation method with lactose and starch as excipients significantly improved the mass properties, enhancing flowability, compressibility, and moisture balance. The obtained results provide a strong basis for producing stable and high-quality tablets in further stages of development.