HORMONES OF SUBCUTANEOUS ADIPOSE TISSUE: FUNCTIONAL ROLES AND CLINICAL SIGNIFICANCE

Abstrak

Subcutaneous adipose tissue (SAT) plays a fundamental role not only in energy storage but also as an active endocrine organ, producing a diverse array of hormones known as adipokines. This study explores the spectrum of adipokines secreted by SAT, including leptin, adiponectin, resistin, and visfatin, and their roles in regulating appetite, insulin sensitivity, inflammation, and systemic metabolism. We analyzed data from 205 patients across varying metabolic health statuses, categorizing them based on their adipokine profiles. Biochemical assays, imaging diagnostics, and lifestyle assessments were employed to explore associations between adipokine dysfunction and chronic conditions such as obesity, metabolic syndrome, and cardiovascular disease. Our results underscore the diagnostic and therapeutic potential of adipokine profiling, suggesting that targeted modulation of adipose-derived hormones could improve outcomes in metabolic disorders.