THE CORRELATION BETWEEN ALZHEIMER’S DISEASE CLINICAL FEATURES AND MRI OBSERVATIONS
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Alzheimer’s disease, MRI, cognitive decline, neurodegeneration, brain atrophy, beta-amyloid, cognitive reserve, gender differences.Abstrak
This article analyzes the correlation between the clinical features of Alzheimer's disease (AD) and magnetic resonance imaging (MRI) observations. Alzheimer's disease is a globally prevalent neurodegenerative disorder characterized by the accumulation of extracellular beta-amyloid plaques, intracellular neurofibrillary tangles of TAU protein, and progressive cognitive decline. The study explores key factors influencing disease progression, including age, genetics, lifestyle, and gender differences. Notably, the higher lifetime risk for women and the impact of educational background on cognitive reserve are highlighted. The research aims to evaluate the potential for early diagnosis by examining how structural brain changes and atrophy detected via MRI correlate with observed clinical symptoms.
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