CURRENT DATA ON CLINICAL-METABOLIC AND IMMUNO-ENDOCRINE DISORDERS IN CHILDREN WITH DOWN SYNDROME: A LITERATURE REVIEW
Keywords:
Down syndrome, children, vitamin D, micronutrients, immunity, endocrine disorders, metabolism.Abstract
Down syndrome is a common chromosomal disorder associated with metabolic, immune, and endocrine abnormalities. This review summarizes current evidence on micronutrient imbalance, vitamin D deficiency, thyroid dysfunction, and immune dysregulation in children with Down syndrome. These disturbances contribute to increased susceptibility to infectious, autoimmune, and metabolic diseases. Early diagnosis and personalized correction are important for improving patient outcomes
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