DISCUSSION OF MEASURES TO IMPROVE THE DIAGNOSIS OF BACTERIAL DISEASES

Abstract

This article's goal is to examine the performance, advantages, and disadvantages of the new and existing microbiological methods that aid in the quick detection of bacterial infections in critically sick patients, as well as the data that is currently available to assess their clinical significance.  Significant morbidity and death are caused by bacterial infections and sepsis in patients hospitalized to the critical care unit, and the growing worldwide burden of antibiotic resistance makes managing these conditions even more difficult.  In this context, novel diagnostic techniques that can surpass the accuracy and turnaround time constraints of conventional microbiology are greatly needed. The optimization of current culture-based techniques, rapid antigen detection, nucleic acid detection (including multiplex PCR assays and microarrays), sepsis biomarkers, new techniques for pathogen detection (like T2 magnetic resonance) and susceptibility testing (like morphokinetic cellular analysis), and the use of direct metagenomics on clinical samples are some of the general topics we cover.