SELECTION OF EXCIPIENTS IN THE DEVELOPMENT OF TECHNOLOGY FOR ANTISPASMODIC TABLETS

Аннотация

The development of antispasmodic tablets requires careful selection of excipients to ensure the tablets' efficacy, stability, and patient compliance. Excipients, which play a crucial role in the formulation of pharmaceutical dosage forms, are non-active ingredients that aid in the manufacturing process and enhance the performance of the active pharmaceutical ingredient (API). In this study, various excipients commonly used in antispasmodic tablet formulations, including binders, disintegrants, lubricants, and stabilizers, were evaluated based on their physicochemical properties and compatibility with the active ingredients. The selection criteria for excipients included their ability to improve the dissolution rate, bioavailability, and stability of the tablets, while minimizing side effects. The influence of these excipients on the mechanical properties and release profile of the tablets was assessed through various in vitro tests. The study highlights the importance of excipient selection in optimizing the formulation and ensuring the desired therapeutic outcomes for patients with gastrointestinal disorders.