ALGORITHM FOR THE EVALUATION AND MANAGEMENT OF PATIENTS WITH MISCARRIAGE ASSOCIATED WITH HORMONAL DISORDERS
Keywords:
Miscarriage, hormonal disorders, management algorithm, progesterone, hypothyroidism, hyperprolactinemia.Abstract
Miscarriage is a significant challenge in modern reproductive medicine, occurring in approximately 10–20% of clinically diagnosed pregnancies. Hormonal disturbances play a crucial role in its development, including luteal phase deficiency, thyroid dysfunction, hyperprolactinemia, and hyperandrogenism. The aim of this study was to develop an algorithm for the evaluation and management of patients with miscarriage associated with endocrine disorders, based on an analysis of current international guidelines and scientific evidence. A review of the literature published between 2018 and 2025 was conducted. It was established that the contemporary approach is based on early diagnosis (after two pregnancy losses), selective hormonal screening, and personalized therapy. An algorithm was developed incorporating stages of diagnosis, risk stratification, and therapeutic decision-making. The application of an algorithm-based approach improves clinical management and reduces the incidence of reproductive loss.
References
ESHRE Guideline Group. Recurrent pregnancy loss guideline. — 2023.
Zhang L. et al. Endocrine dysfunction in recurrent pregnancy loss // Frontiers in Endocrinology. — 2023.
Kharun I.L. et al. Endocrine causes of recurrent pregnancy loss. — 2023.
NICE. Ectopic pregnancy and miscarriage: diagnosis and management. — 2021.
Turesheva A. et al. Risk factors of recurrent pregnancy loss. — 2023.
Coomarasamy A. et al. Progesterone therapy (PRISM trial) // N Engl J Med. — 2019.
Medina L. et al. Thyroid autoimmunity and miscarriage // Medicina. — 2021.
Teede H. et al. PCOS guideline // 2023.
Abdukhamidovna K. D. GENETIC TESTS AND THEIR ROLE IN OBSTETRIC AND GYNAECOLOGICAL CARE //Eurasian Journal of Medical and Natural Sciences. – 2024. – Т. 4. – №. 10. – С. 61-64.
Abdukhamidovna K. D. MODERN APPROACHES TO PREVENTION AND TREATMENT OF SEXUALLY TRANSMITTED INFECTIONS //Eurasian Journal of Academic Research. – 2024. – Т. 4. – №. 10. – С. 59-63.
Xasanova D. A. HOMILADORLIKDA TURLI ENDOKRIN BUZILISHLAR VA ULARNI OLDINI OLISH YO ‘LLARINI ISHLAB CHIQISH //Журнал гуманитарных и естественных наук. – 2025. – №. 22 [1]. – С. 179-182.
Мусинжанова П. С. и др. ЗНАЧЕНИЕ ВОСПАЛИТЕЛЬНЫХ ПРОЦЕССОВ ГЕНИТАЛИЙ В ПРОИСХОЖДЕНИИ ЖЕНСКОГО БЕСПЛОДИЯ (ОБЗОР ЛИТЕРАТУРЫ) //International scientific review of the problems of natural sciences and medicine. – 2019. – С. 136-149.
Хасанова Д., Камалова Д. Диагностика аутоиммунного тиреоидита у беременных и изучение исходов родов //Журнал биомедицины и практики. – 2021. – Т. 1. – №. 3/2. – С. 14-18.
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