METHODS FOR EVALUATING THE QUALITY AND QUANTITATIVE INDICATORS OF “CLARIN” TABLETS COVERED WITH A COATING
;
Tablet, quality indicators, purity, disintegration, dissolution test, average weight, impurities, quantitative analysis, microbiological purityAbstrak
This article analyzes the main approaches to assessing the quality indicators of “Clarin” 250 mg and 500 mg coated tablets. The appearance, purity, disintegration time, solubility, average mass, amount of impurities, quantitative composition, and microbiological purity of the preparations were comprehensively studied. The results obtained showed that the use of modern analytical methods and standard samples is important for accurate quality assessment. At the same time, the studies have provided the necessary practical and theoretical basis for further improving the requirements for tablet dosage forms and scientifically justifying regulatory documents.
Iqtiboslar
Lozano R., Naghavi M., Foreman K., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 //Lancet. - 2013.- 380.-P. 2095-2128
Lim S. S., Vos T., Flaxman A. D., et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters
in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease
Study 2010 // Lancet.- 2013.- 80.-P. 2224-2260.
The American Society of Health-System Pharmacists (ASHP) 2015 Midyear Clinical Meeting // New Orleans, Louisiana December.-2015.- P. 06 -10.
Ковалева Е.Л., Матвеева О.А., Колганова Е.Е., Миронова М.М. Актуальные вопросы оценки качества препаратов в лекарственной форме «таблетки»// Регуляторные исследования и экспертиза лекарственных средств. -2015.-C.-54-57.
Алексеев К.В., Кедик С.А., Блынская Е.В., Алексеев В.К., Масленникова Н.В. Фармацевтическая технология.
Таблетки. М: ЗАО ИФТ.-2015.- C.-672 .
Карпов И.А., Качанко Э.Ф. Кларитромицин: возможности клинического исползования //Медицинские новости.-2012. -Вып.1.- С.68-72.- ISSN 2076-4812
O’zbekiston Respublikasi davlat farmakopeyasi 1-nashr, 1-jild, 1-qism. Toshkent.-2021.
FSP 42-Uz-25938724-5832-2025. “Кlarin” qobiq bilan qoplangan tabletkalar 250 mg, 500 mg.
Maksudova F.X., Nusratova N.N. Klaritromitsin substansiyasi asosida qobiqli tabletkalarning tarkibi va texnologiyasini ishlab chiqish// Farmasevtika jurnali. Toshkent-2026. №2 B. 45-55.
##submission.downloads##
Nashr qilingan
Nashr
Bo'lim
Iqtibos keltirish tartibi
