PHENOLIC GLYCOSIDE – ARBUTIN FROM THE PLANT ONOBRYCIS GRANDIS LIPSKY AND ITS BIOLOGICAL ACTIVITY

Abstract

From the aerial part of the plant Onobrychis grandis Lipsky (Fabaceae) growing in the territory of Uzbekistan, the phenolic glycoside arbutin was isolated. The parameters of the acute toxicity of arbutin were determined, its analgesic activity was studied in the tests “hot plate,” “acetic writhing” and “acetylcholine writhing.” It was shown that arbutin belongs to low-hazard substances (Class IV according to GOST 12.1.007-76) and practically non-toxic compounds (Class VI according to the classification of A.V. Stefanov). The compound showed pronounced analgesic activity in thermal and chemical (acetic acid) irritation, but did not show a significant effect in the acetylcholine writhing test.