Articles

PERSONALIZED THERAPY OF CHRONIC DAILY HEADACHES: THE IMPORTANCE OF GENETIC AND VASCULAR MARKERS

Vol. 5 No. 8 (2025): Eurasian Journal of Medical and Natural Sciences 56-59

2025-08-18 Articles CC BY 4.0 Open Access

Authors

  • Нигора Кадырходжаева PhD. Central Asian University, Ташкент, Узбекистан Университетская клиника Akfamedline, Ташкент, Узбекистан
  • Анна Прохорова Центр сенсорной интеграции и развития речи, Ташкент, Узбекистан. Доктор медицинских наук.

Abstract

This article highlights the significance of a personalized approach in the treatment of chronic daily headaches (CDH). Special attention is given to the role of genetic and vascular markers in the pathogenesis of the disease and the effectiveness of therapy. Genetic factors play a key role in determining the individual characteristics of headaches and in predicting the body’s response to medications. Vascular markers allow the assessment of changes in cerebral circulation and brain trophics. The results of scientific analysis demonstrate that the use of personalized therapy can enhance treatment effectiveness, reduce side effects, and improve patients’ quality of life.

Keywords:

References

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Jiménez-Sánchez L, et al. Role of homocysteine in migraine: pathways, genes and pharmacogenetics. Pharmacol Res. 2021;167:105576.

Kowa H, et al. The influence of MTHFR gene polymorphism on the efficacy of triptans in migraine attacks. Neurology. 2012;78(7):544-547.

Ke X, et al. The link between hyperhomocysteinemia and vascular cognitive impairment: A meta-analysis. Neurosci Biobehav Rev. 2021;126:146-158.

Bockowski L, Sobaniec W, Kulak W. Plasma homocysteine and B vitamins in children with migraine. Headache. 2005;45(4):346-352.

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Published

2025-08-18

How to Cite

Кадырходжаева , Н. ., & Прохорова , А. . (2025). PERSONALIZED THERAPY OF CHRONIC DAILY HEADACHES: THE IMPORTANCE OF GENETIC AND VASCULAR MARKERS. Eurasian Journal of Medical and Natural Sciences, 5(8), 56-59. https://www.in-academy.uz/index.php/EJMNS/article/view/11121
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