PHARMACOLOGICAL PROPERTIES OF GLYCYRRHETINIC ACID DERIVATIVES: A CRITICAL ANALYSIS OF RECENT SCIENTIFIC STUDIES

Аннотация

Glycyrrhetinic acid (GA), the aglycone metabolite of glycyrrhizin derived from Glycyrrhiza glabra (licorice), has attracted significant attention due to its broad spectrum of biological activities. Recent advances in medicinal chemistry have enabled the synthesis of numerous glycyrrhetinic acid derivatives with enhanced pharmacological properties. The present study critically analyzes three recent peer-reviewed publications investigating the antimicrobial, anti-inflammatory, and antitumor activities of glycyrrhetinic acid derivatives. A systematic review approach was applied to evaluate experimental design, pharmacological efficacy, mechanisms of action, and structure–activity relationships (SAR). The findings demonstrate that chemical modifications of glycyrrhetinic acid significantly improve biological activity and therapeutic potential. The reviewed studies suggest that glycyrrhetinic acid derivatives represent promising candidates for the development of novel anti-infective, anti-inflammatory, and anticancer agents.