THE APPLICATION OF SILIBUM MARIANUM GAERTN.L. IN THE TREATMENT OF ONCOLOGICAL DISEASES

Abstract

Silibum marianum Gaertn.L., commonly known as milk thistle, has long been used in traditional medicine for its hepatoprotective effects. Recent studies have expanded its potential applications, highlighting its promising role in the treatment and support of oncological diseases. This article explores the pharmacological properties of its primary bioactive compound, silymarin, with a particular focus on its antioxidant, anti-inflammatory, and anti-carcinogenic mechanisms. The advantages of Silibum marianum over conventional therapies—such as low toxicity, selective cytotoxicity against tumor cells, and synergistic potential with chemotherapeutic agents—are discussed in detail. Additionally, current challenges including limited clinical evidence, low bioavailability, and the need for standardized formulations are addressed. The article concludes by outlining future research directions and emphasizing the plant’s potential as part of an integrative approach to cancer care.