GLYCYRRHETINIC ACID DERIVATIVES: PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC POTENTIAL IN MODERN DRUG DEVELOPMENT
Keywords:
Results. Chemical analysis demonstrated that the C-3 hydroxyl group, C-11 carbonyl group and C-30 carboxyl group are the primary sites used for structural modification.Abstract
Glycyrrhetinic acid (GA) is a pentacyclic triterpenoid obtained from glycyrrhizin, the major bioactive constituent of licorice. During the last decade, GA derivatives have attracted considerable attention because of their anticancer, anti-inflammatory, antiviral, antioxidant, hepatoprotective and antimicrobial activities. This review analyzes five DOI-indexed studies and evaluates the relationship between chemical structure and pharmacological activity. The findings demonstrate that modifications at the C-3, C-11 and C-30 positions significantly improve biological activity and pharmacokinetic characteristics. The reviewed evidence suggests that GA derivatives are promising lead compounds for future drug development.
References
Chen L. et al. A Review of Typical Biological Activities of Glycyrrhetinic Acid and Its Derivatives. DOI: 10.1039/D3RA08025K.
Xu B. et al. An Overview of Structurally Modified Glycyrrhetinic Acid Derivatives as Antitumor Agents. DOI: 10.3390/molecules22060924.
Hussain H. et al. Glycyrrhetinic Acid: A Promising Scaffold for the Discovery of Anticancer Agents. DOI: 10.1080/17460441.2021.1956901.
Yang Y. et al. Synthesis and Biological Activity of Glycyrrhetinic Acid Derivatives as Antitumor Agents. DOI: 10.1016/j.ejmech.2019.06.029.
Pan B.W. et al. Synthesis and Antiviral and Antitumor Activities of Novel 18β-Glycyrrhetinic Acid Derivatives. DOI: 10.3390/ijms241915012.
Downloads
Published
Issue
Section
How to Cite
