NOALKOGOL JIGAR YOG'LI KASALLIGIDA SERAMID DARAJASINING LIPID SPEKTRI VA JIGAR ZARARLANISHI KO'RSATKICHLARI BILAN O'ZARO BOG'LIQLIGI
Том 5 № 25 (2026): Инновационные исследования в современном мире 74-75
Аннотация
Noalkogol jigar yog'li kasalligi (NJYK) rivojlanishida lipid almashinuvi buzilishlari markaziy o'rin tutadi, biroq an'anaviy lipid spektri ko'rsatkichlari kasallikning og'irlik darajasini yetarlicha aks ettirmaydi. Sfingolipidlar metabolizmining oraliq va signal mahsuloti bo'lgan seramidning boshqa lipid fraksiyalari hamda jigar zararlanishining instrumental va biokimyoviy belgilari bilan o'zaro munosabatini aniqlash kasallik patogenezini chuqurroq tushunish va lipid tekshiruvlarining diagnostik qiymatini oshirish imkonini beradi.
Библиографические ссылки
Pagadala M., Kasumov T., McCullough A.J., Zein N.N., Kirwan J.P. Role of ceramides in nonalcoholic fatty liver disease // Trends in Endocrinology and Metabolism. – 2012. – Vol. 23, No. 8. – P. 365–371.
Carlier A., Phan F., Szpigel A., Hajduch E., Salem J.E., Gautheron J. et al. Dihydroceramides in triglyceride-enriched VLDL are associated with nonalcoholic fatty liver disease severity in type 2 diabetes // Cell Reports Medicine. – 2020. – Vol. 1, No. 9. – Article 100154.
Luukkonen P.K., Zhou Y., Sädevirta S., Leivonen M., Arola J., Orešič M. et al. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease // Journal of Hepatology. – 2016. – Vol. 64, No. 5. – P. 1167–1175.
Ooi G.J., Meikle P.J., Huynh K., Earnest A., Roberts S.K., Kemp W. et al. Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis // Journal of Hepatology. – 2021. – Vol. 75, No. 3. – P. 524–535.
Denimal D., Béland-Bonenfant S., Pais-de-Barros J.P., Rouland A., Bouillet B., Duvillard L. et al. Plasma ceramides are associated with MRI-based liver fat content but not with noninvasive scores of liver fibrosis in patients with type 2 diabetes // Cardiovascular Diabetology. – 2023. – Vol. 22. – Article 310.
Maldonado-Hernández J., Saldaña-Dávila G.E., Piña-Aguero M.I., Núñez-García B.A., López-Alarcón M.G. Association between plasmatic ceramides profile and AST/ALT ratio: C14:0 ceramide as predictor of hepatic steatosis in adolescents independently of obesity // Canadian Journal of Gastroenterology and Hepatology. – 2017. – Vol. 2017. – Article 3689375.
География читателей
Загрузки
Опубликован
Выпуск
Раздел
Как цитировать
