Tibbiyot, farmatsevtika va biologiya

ПЛАСТИК МИКРОЗАРРАЧАЛАРИНИ ИСТЕЪМОЛ ҚИЛГАН ОҚ СИЧҚОНЛАР ЙЎҒОН ИЧАГИНИНГ МОРФОФУНКЦИОНАЛ ХУСУСИЯТЛАРИ

Jild 5 son 25 (2026) 63-67

2026-09-12 Tibbiyot, farmatsevtika va biologiya CC BY 4.0 Open Access

Mualliflar

  • Саидова Ф.И. Абу Али ибн Сино номидаги Бухоро давлат тиббиёт институти, Бухоро ш., Ўзбекистон,

Annotatsiya

Овқат ҳазм қилиш тизими микропластик таъсирнинг энг муҳим йўли ҳисобланади ва инсоннинг биологик намуналарида микропластикнинг энг юқори концентрациялари айнан ичакларда аниқланган. Йўғон ичакнинг функционал хусусиятларидан келиб чиққан ҳолда микропластикнинг салбий таъсирини ушбу аъзода ўрганиб чиқиш аҳамиятли ҳисобланади. Микропластик эпителиал ҳужайраларнинг пролиферацияси, апоптози ва дифференциациясига, метаболизмга ва ичак микрофлораси таркибига таъсир кўрсатади.

Kalit soʻzlar:

Iqtiboslar

Barceló D, Picó Y, Alfarhan AH. Microplastics: Detection in human samples, cell line studies, and health impacts. Environ Toxicol Pharmacol. 2023;101:104204.

Covello C, Di Vincenzo F, Cammarota G, Pizzoferrato M. Micro(nano)plastics and their potential impact on human gut health: a narrative review. Current Issues in Molecular Biology. 2024;46:2658–2677.

Choi YJ, Kim JE, Lee SJ, Gong JE, Jin YJ, Seo S, Lee JH, Hwang DY. Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks. Laboratory Animal Research. 2021;37:31.

Deng Y, Zhang Y, Lemos B, Ren H. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Scientific Reports. 2017;7:46687.

Djouina M, Vignal C, Dehaut A, Caboche S, Hirt N, Waxin C, et al. Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice. Environmental Research. 2022;212:113230.

Guan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. Journal of Immunology Research. 2019;2019:7247238.

Huang J, Sun X, Wang Y, Su J, Li G, Wang X, Yang Y, Zhang Y, Li B, Zhang G, Li J, Du J, Nanjundappa RH, Umeshappa CS, Shao K. Biological interactions of polystyrene nanoplastics: their cytotoxic and immunotoxic effects on the hepatic and enteric systems. Ecotoxicology and Environmental Safety. 2023;264:115447.

Jia R, Han J, Liu X, Li K, Lai W, Bian L, Yan J, Xi Z. Exposure to polypropylene microplastics via oral ingestion induces colonic apoptosis and intestinal barrier damage through oxidative stress and inflammation in mice. Toxics. 2023;11:127.

Li B, Ding Y, Cheng X, Sheng D, Xu Z, Rong Q, Wu Y, Zhao H, Ji X, Zhang Y. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice. Chemosphere. 2020;244:125492.

Liang B, Zhong Y, Huang Y, Lin X, Liu J, Lin L, Hu M, Jiang J, Dai M, Wang B, Zhang B, Meng H, Lelaka JJJ, Sui H, Yang X, Huang Z. Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis. Particle and Fibre Toxicology. 2021;18:20.

Liu S, Wang Z, Xiang Q, Wu B, Lv W, Xu S. A comparative study in healthy and diabetic mice followed the exposure of polystyrene microplastics: differential lipid metabolism and inflammation reaction. Ecotoxicology and Environmental Safety. 2022;244:114031.

Ma J, Wan Y, Song L, Wang L, Wang H, Li Y, Huang D. Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism. Particle and Fibre Toxicology. 2023;20:49.

Park SB, Jung WH, Choi KJ, Koh B, Kim KY. A comparative systematic analysis of the influence of microplastics on colon cells, mouse and colon organoids. Tissue Engineering and Regenerative Medicine. 2023;20:49–58.

Sun H, Chen N, Yang X, Xia Y, Wu D. Effects induced by polyethylene microplastics oral exposure on colon mucin release, inflammation, gut microflora composition and metabolism in mice. Ecotoxicology and Environmental Safety. 2021;220:112340.

Wen S, Zhao Y, Liu S, Chen Y, Yuan H, Xu H. Polystyrene microplastics exacerbated liver injury from cyclophosphamide in mice: insight into gut microbiota. The Science of the Total Environment. 2022;840:156668.

Xie S, Zhang R, Li Z, Liu C, Chen Y, Yu Q. Microplastics perturb colonic epithelial homeostasis associated with intestinal overproliferation, exacerbating the severity of colitis. Environmental Research. 2023;217:114861.

Yang Y-F, Chen C-Y, Lu T-H, Liao C-M. Toxicity-based toxicokinetic/toxicodynamic assessment for bioaccumulation of polystyrene microplastics in mice. Journal of Hazardous Materials. 2019;366:703–713.

Yu C, Xu Y, Wei Y, Guo Y, Wang Y, Song P, Yu J. Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice. Environmental Science and Pollution Research International. 2024;31:6527–6542.

Zha H, Tang R, Li S, Zhuge A, Xia J, Lv J, Wang S, Wang K, Zhang H, Li L. Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice. Chemosphere. 2024;349:140940.

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    Tibbiyot, farmatsevtika va biologiya

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    Саидова, Ф. (2026). ПЛАСТИК МИКРОЗАРРАЧАЛАРИНИ ИСТЕЪМОЛ ҚИЛГАН ОҚ СИЧҚОНЛАР ЙЎҒОН ИЧАГИНИНГ МОРФОФУНКЦИОНАЛ ХУСУСИЯТЛАРИ. Zamonaviy Dunyoda Ilm-Fan Va Texnologiya, 5(25), 63-67. https://www.in-academy.uz/index.php/ZDIFT/article/view/57235
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