EVALUATION OF THE CYTOTOXIC ACTIVITY OF A GLYCYRRHETINIC ACID DERIVATIVE IN DIFFERENT STANDARD CANCER CELL LINES
Keywords:
glycyrrhetinic acid, 18β-glycyrrhetinic acid, cytotoxicity, cancer cell lines, MCF-7, MDA-MB-231, HeLa, A549, anticancer activity, apoptosis, IC50, DOI..Abstract
Glycyrrhetinic acid is a pentacyclic triterpenoid aglycone derived from licorice and is widely recognized for its anti-inflammatory, hepatoprotective, antiviral, antioxidant, and anticancer properties. In recent years, considerable attention has been directed toward the synthesis of semisynthetic GA derivatives and the evaluation of their cytotoxic activity against standard human cancer cell lines. The present article aims to analyze the cytotoxic activity of glycyrrhetinic acid derivatives in accordance with the IMRAD structure, using only three original studies published in reputable peer-reviewed journals with real and verifiable DOI numbers. The analysis includes papers published in Molecules (2016), Biological and Pharmaceutical Bulletin (2020), and Molecules (2023). These studies collectively describe the cytotoxic profile of GA derivatives in MCF-7, MDA-MB-231, HeLa, SGC-7901, BEL-7402, A549, B16, and LO2 cell lines.
References
Li Y., Feng L., Song Z.-F., Li H.-B., Huai Q.-Y. Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives. Molecules. 2016;21(2):199. DOI: 10.3390/molecules21020199.
Zheng Q.-X., Wang R., Xu Y., He C.-X., Zhao C.-Y., Wang Z.-F., Zhang R., Dehaen W., Li H.-J., Huai Q.-Y. Design, Preparation and Studies Regarding Cytotoxic Properties of Glycyrrhetinic Acid Derivatives. Biological and Pharmaceutical Bulletin. 2020;43(1):102–109. DOI: 10.1248/bpb.b19-00615.
Chen J., Xu Y., Yang Y., Yao X., Fu Y., Wang Y., Liu Y., Wang X. Evaluation of the Anticancer Activity and Mechanism Studies of Glycyrrhetic Acid Derivatives toward HeLa Cells. Molecules. 2023;28(7):3164. DOI: 10.3390/molecules28073164.
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