Eurasian Journal of Medical and Natural Sciences

In this article, it is shown that the healing properties of the plant Anthemis tinctoria L. are associated with the presence of polyacetylene in its roots, flavonoids, glucosides, and essential oil compounds in its flowers. In addition, this plant contains quercetin, rubber, Vitamin P, xanthophyll, dyes, and alkaloids beneficial for the human body. In this case, a number of experiments were conducted using the following isolators to isolate the active biologically active substance from the plant yellow chamomile (Anthemis tinctoria L.). As a separator, purified water, ethyl alcohol with different percentage concentrations, i.e., 40, 70, 90, 96% ethyl alcohol, were used. Using the HPLC method, the content of flavonoids in the liquid extract obtained from the raw material of the plant Anthemis tinctoria L. was determined, which was carried out in the "Agilent 1260 Infinity" mode, spectrophotometric detector, chromatographic column Agilent S18 5 μm, 4.6x250 mm, gradient mode.

The article emphasizes that accurate physiological interpretation of blood parameters requires a shift from a "slice of values" to modeling time dynamics and contextual normalization for individual conditions. It is concluded that the most promising approach is the integration of cellular, biochemical, and rheological data into unified functional indices, enabling the comparison of adaptation profiles and the identification of early dysregulation before clinical manifestations.

Disturbances in water balance in the body significantly affect numerous physiological processes. Under conditions of dehydration, hemoconcentration, microcirculatory disorders, and tissue hypoxia may negatively influence various components of the immune system, particularly gut-associated lymphoid tissues. The intestinal lymphatic system, including Peyer’s patches and solitary lymphoid follicles, plays an important role in the formation of local immune responses. The aim of this study was to determine the morphological and morphometric changes in the lymphoid follicles of the small intestine under conditions of experimental dehydration. The study was carried out under laboratory conditions using white rats as an experimental model. In the experimental group of animals, dehydration was induced by restricting fluid intake. The obtained intestinal tissues were examined using histological methods followed by detailed morphological analysis. The results of the study demonstrated that dehydration leads to a decrease in the number of lymphocytes within intestinal lymphoid follicles, alterations in cellular composition, and morphological restructuring of the lymphatic capillary network. In addition, dystrophic and destructive processes in the intestinal wall layers were observed to intensify. The obtained results contribute to a better understanding of structural changes in the intestinal immune system under dehydration conditions and help clarify the pathomorphological mechanisms associated with water deficiency in the organism

Pulpitis is an inflammatory condition of the dental pulp and is one of the most common diseases in therapeutic dentistry. This paper analyzes the etiology, clinical features, and modern treatment methods of pulpitis. Special attention is given to biological (conservative) treatment, vital amputation, and devital extirpation methods. The use of modern anesthesia techniques and advanced dental materials significantly increases treatment effectiveness. The correct selection of treatment methods plays a crucial role in preserving tooth function

Body mass index is considered an important factor influencing women’s reproductive and somatic health. Objective: To investigate the structure of gynecological and somatic pathology in women of reproductive age according to body mass index. Materials and Methods: A retrospective analytical study included 448 women aged 18–49 years who were hospitalized between 2022 and 2026. Patients were stratified into three groups according to body mass index: normal weight, overweight, and obesity. Results: Type 2 diabetes mellitus was most frequently detected in women with obesity (78.1%), whereas endometrial hyperplasia was more common among women with overweight (46.2%). Conclusion: Body mass index is associated with the structure of gynecological and somatic pathology in women of reproductive age.

Fetal ventriculomegaly occupies a special place among prenatally detected malformations of the central nervous system. In severe forms, even when isolation of the defect is confirmed, the risk of an unfavorable neurological outcome remains high. The question of the possibility of prenatal correction has remained open for nearly forty years.

As a result of the conducted research, the presence of 40 mineral elements was established in the leaves of common basil. Toxic heavy metals (As, Pb, Hg, Cd), subject to priority control, in the studied raw material were determined within the permissible limits adopted by the World Health Organization and the State Pharmacopoeia of the Russian Federation, XIV edition, for medicinal plant raw materials and preparations based on them, as well as SanPiN 1.10.7 for biologically active supplements of plant origin, which indicates their ecological safety. The obtained data will be in demand for the chemical characterization of the raw material and its subsequent standardization.

to assess the main indicators of perinatal service development in the Fergana region for 2010-2024 and to identify ways of its improvement.

This article presents the results of research on the development of methods for the identification and quantitative determination of ascorbic acid in dietary supplements in the form of gummy pastilles. Given the complex matrix of the gummy dosage form, which contains gelling agents and sugars, High-Performance Liquid Chromatography (HPLC) with UV detection was selected for the analysis. Titrimetric determination using sodium 2,6-dichloroindophenolate was used as a comparative method. It was established that the developed HPLC method is characterized by high selectivity and reproducibility. The content of ascorbic acid in one gummy pastille ranged from 10.1 to 10.3 mg. The results obtained confirm the feasibility of using the proposed method for the quality control of dietary supplements in gummy forms.

It has been established that propolis (bee glue) is a complex multicomponent system with pronounced antioxidant and pleotropic effects, in demand in food technologies as a multifunctional agent and preservative

The aim of this study was to develop and simulate a Weibull mathematical model based on experimentally derived dissolution profiles of Aferol tablets (active ingredient: ferrous fumarate 210 mg, equivalent to 65 mg Fe²⁺) in order to quantitatively assess the influence of key technological factors on the kinetics of active substance release. Particular emphasis was placed on the effects of compression pressure (100–300 MPa), tablet geometrical characteristics (diameter 8–10 mm, surface area), composition of excipients (magnesium stearate 0.5–2 %, corn starch, colloidal silicon dioxide, talc, polyvinylpyrrolidone), particle size distribution of the granulate, and residual granulate moisture content (1.25–3 %).

This article presents an analysis of drugs used for gallbladder diseases in the local pharmaceutical market. The study utilizes data registered in 2023-2025 based on the State Register of the Republic of Uzbekistan. The obtained data demonstrate the need to expand the range of these types of drugs in domestic production.

The antiradical activity of aqueous extracts of mixtures of tansy (Tanacetum vulgare L.) and horsetail (Equisetum arvense L.) in ratios of 1:1, 1:3, and 3:1 was studied. Extracts were obtained by ultrasonic extraction of the aboveground plant parts with distilled water. Antioxidant activity was assessed by the degree of DPPH radical inhibition (λ = 517 nm) upon addition of various volumes of extract, followed by calculation of AOF% and IC₅₀. The results were compared with previously studied ethanol extracts.

Forecasting pharmaceutical market dynamics characterized by pronounced seasonal fluctuations remains a methodological challenge for healthcare planning systems. This study proposes a methodology for forecasting pharmaceutical market indicators using a seasonality index, demonstrated on the example of anthelmintic drugs. Monthly data from the Drug Audit database covering the period 2009–2024 were analyzed, and forecast estimates were developed up to 2031 using a multiplicative time series model and a scenario-based approach including baseline, optimistic, and pessimistic scenarios. To our knowledge, limited studies have applied seasonality-index-based forecasting to the pharmaceutical market of anthelmintic drugs. The methodology was tested both at the level of individual International Nonproprietary Names (albendazole, mebendazole, and pyrantel) and at the level of the aggregated anthelmintic market. The results demonstrate that incorporating seasonality indices improves the reliability of demand forecasting and supports evidence-based pharmaceutical supply planning and decision-making.

Miscarriage remains one of the most pressing issues in contemporary reproductive medicine, occurring in approximately 10–20% of clinically recognized pregnancies. Endocrine disturbances play a substantial role in its pathogenesis, including luteal phase deficiency, thyroid dysfunction, hyperandrogenism, and hyperprolactinemia. According to current data, hormonal factors account for approximately 8–17% of miscarriage cases. The aim of this review was to analyze recent evidence on the role of hormonal disorders in the development of reproductive loss. Publications from the past 5–10 years were reviewed. The findings indicate that thyroid disorders, progesterone deficiency, and metabolic endocrinopathies are among the most significant factors. Comprehensive diagnostics and personalized therapeutic approaches can improve the likelihood of a favorable pregnancy outcome.

Miscarriage is a significant challenge in modern reproductive medicine, occurring in approximately 10–20% of clinically diagnosed pregnancies. Hormonal disturbances play a crucial role in its development, including luteal phase deficiency, thyroid dysfunction, hyperprolactinemia, and hyperandrogenism. The aim of this study was to develop an algorithm for the evaluation and management of patients with miscarriage associated with endocrine disorders, based on an analysis of current international guidelines and scientific evidence. A review of the literature published between 2018 and 2025 was conducted. It was established that the contemporary approach is based on early diagnosis (after two pregnancy losses), selective hormonal screening, and personalized therapy. An algorithm was developed incorporating stages of diagnosis, risk stratification, and therapeutic decision-making. The application of an algorithm-based approach improves clinical management and reduces the incidence of reproductive loss.