ОПРЕДЕЛЕНИЕ ВЛИЯНИЯ ТЕХНОЛОГИЧЕСКИХ ФАКТОРОВ НА ВЫСВОБОЖДЕНИЕ ЖЕЛЕЗА ФУМАРАТА ИЗ ТАБЛЕТОК АФЕРОЛ МЕТОДОМ МАТЕМАТИЧЕСКОГО МОДЕЛИРОВАНИЯ
Article Sidebar
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Main Article Content
Аннотация:
Hазработать и симулировать математическую модель Вейбулла на основе экспериментально полученных профилей растворения таблеток Аферол (действующее вещество: железа фумарат - 210 мг, экв. 65 мг Fe²⁺) для количественной оценки влияния ключевых технологических факторов на кинетику высвобождения действующего вещества. Основное внимание уделено влиянию давления прессования (100–300 МПа), геометрическим характеристикам таблетки (диаметр 8–10 мм, площадь поверхности), составу вспомогательных веществ (стеарат магния 0,5–2 %, крахмал, диоксид кремния, тальк, ПВП), гранулометрическому составу гранулята и остаточной влажности (1,25–3 %).
Article Details
Как цитировать:
Библиографические ссылки:
Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences. 2001;13(2):123–133. https://doi.org/10.1016/S0928-0987(01)00095-1
Langenbucher F. Linearization of dissolution rate curves by the Weibull distribution. Journal of Pharmacy and Pharmacology. 1972;24(12):979–981. https://doi.org/10.1111/j.2042-7158.1972.tb08930.x
Papadopoulou V, Kosmidis K, Vlachou M, Reppas C. On the use of the Weibull function for the description of in vitro drug release. International Journal of Pharmaceutics. 2006;309(1–2):44–50. https://doi.org/10.1016/j.ijpharm.2005.10.044
Basualdo S, Spinelli V, Torres M, et al. Comparison of dissolution profiles of formulations containing ferrous sulfate and ferrous fumarate. Dissolution Technologies. 2012;19(4):47–55. https://doi.org/10.14227/DT190412P47
Patrício JPH, et al. In vitro dissolution profile of two commercially available iron- and folic acid-containing supplements. ISRN Pharmaceutics. 2012;2012:Article ID 601067. https://doi.org/10.5402/2012/601067
Adeleye OA, et al. Relationship between compression pressure, mechanical strength and release properties of tablets prepared by direct compression. Polimery. 2019;64(1):27–36. https://doi.org/10.14314/polimery.2019.1.5
Khan KA, Rhodes CT. Effect of compaction pressure on the dissolution efficiency of some direct compression systems. Pharmaceutica Acta Helvetiae. 1972;47(10):594–607.
Markl D, Zeitler JA. A review of disintegration mechanisms and measurement techniques. Pharmaceutical Research. 2017;34(5):890–917. https://doi.org/10.1007/s11095-017-2122-z
Ferdoush S, et al. Semi-mechanistic reduced order model of pharmaceutical tablet dissolution. International Journal of Pharmaceutics. 2022;612:121345. https://doi.org/10.1016/j.ijpharm.2021.121345
Bolourchian N, Dadashzadeh S. The effect of formulation variables on the release of iron from ferrous fumarate tablets. DARU Journal of Pharmaceutical Sciences. 2008;16(4):233–239.
Desai D, et al. Effect of magnesium stearate lubrication on tablet properties: impact of blending time and lubricant level. AAPS PharmSciTech. 2010;11(3):1234–1243. https://doi.org/10.1208/s12249-010-9496-8
Kushner J, et al. The effect of magnesium stearate blending time on tablet hardness and dissolution. Pharmaceutical Development and Technology. 2010;15(5):462–470. https://doi.org/10.3109/10837450903332994
Jonebring A, et al. Magnesium stearate – a critical excipient in tablet manufacturing: impact on tablet properties and dissolution. European Journal of Pharmaceutics and Biopharmaceutics. 2019;144:1–10. https://doi.org/10.1016/j.ejpb.2019.08.014
Sun CC. Setting the bar for powder compaction: a critical review of tabletability. Journal of Pharmaceutical Sciences. 2019;108(3):1035–1043. https://doi.org/10.1016/j.xphs.2018.10.033
Tye CK, Sun CC, Amidon GE. Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. Journal of Pharmaceutical Sciences. 2005;94(2):465–472. https://doi.org/10.1002/jps.20262
Bolourchian N, Dadashzadeh S. The effect of particle size on the dissolution rate of ferrous fumarate from tablets. Iranian Journal of Pharmaceutical Research. 2007;6(4):227–233.
Yu LX. Pharmaceutical quality by design: product and process development, understanding, and control. Pharmaceutical Research. 2008;25(4):781–791. https://doi.org/10.1007/s11095-007-9511-1
Н.Б.Илхамова, Ш.А.Касимова. Выбор вспомогательных веществ для таблеток на основе фумарата железа. Глобальная наука и инновация 2023: Центральная Азия. 2023. № 1(19). Сер. Химические науки. Т. 2. С. 24–25.