IN VITRO EVALUATION OF CYTOTOXICITY AND BIOCOMPATIBILITY OF GRAPE SEED EXTRACT-LOADED SNEDDS GEL IN HACAT AND CACO-2 CELL MODELS

Abstract

Self-nanoemulsifying drug delivery systems (SNEDDS) have emerged as promising platforms for improving the solubility and bioavailability of poorly water-soluble compounds, particularly plant-derived bioactives. In the present study, SNEDDS-based formulations were developed and incorporated into a Carbopol hydrogel and further combined with a non-ionic hydrophilic ointment base to obtain a semi-solid delivery system suitable for topical application.