CYTOTOXIC EVALUATION OF SMALL DRUG-LIKE MOLECULES (ASPIRIN ANALOGUES) AGAINST HUMAN COLORECTAL CANCER CELLS

Abstract

Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide, highlighting the urgent need for new and effective anticancer agents. This study evaluated the cytotoxic activity of eight aspirin analogues (A1, A2, B1, B2, C1, C2, D1, D2) against human colorectal cancer H630 WT cell lines. The results showed that the degree of growth inhibition varied depending on the structural differences among the compounds. The analogues A2, B1, B2, and D2 demonstrated the most pronounced cytotoxic activity, significantly reducing cell viability. These findings suggest that especially A2, B2, and D2 are promising candidates for further investigation as potential anticancer agents in the treatment of colorectal cancer.