THE ROLE OF STAPHYLOCOCCUS AUREUS IN THE DEVELOPMENT OF BACTERIAL CONJUTIVITIS
DOI:
https://doi.org/10.5281/zenodo.20206008Keywords:
Bacterial conjunctivitis, Staphylococcus aureus, eye infection, purulent discharge, antibiotic resistance, MRSA.Abstract
This article analyzes the pathogenic properties, transmission mechanisms, clinical signs, and diagnostic and treatment approaches of Staphylococcus aureus, one of the main etiological factors of bacterial conjunctivitis. Staphylococcus aureus is one of the important microorganisms that cause inflammation in the conjunctiva of the eye, and its ability to produce toxins, form biofilms, and resistance to antibiotics play an important role in the development of the disease. The article reviews the clinical course of bacterial conjunctivitis associated with this bacterium and modern treatment methods.
References
Alfonso S.A., Fawley J.D., Lu X.A. Conjunctivitis. Prim. Care Clin. Off. Pract. 2015;42:325–345. doi: 10.1016/j.pop.2015.05.001. [DOI] [PubMed] [Google Scholar]
American Academy of Ophthalmology. Preferred Practice Pattern: Conjunctivitis. 2023.
Azari A.A., Barney N.P. Conjunctivitis: A systematic review of diagnosis and treatment. JAMA. 2013;310:1721–1730. doi: 10.1001/jama.2013.280318. [DOI] [PMC free article] [PubMed] [Google Scholar]
Cavet ME, Harrington KL, Ward KW, et al. The effect of topical probiotics on ocular surface microbiome and inflammation.Ocul Surf. 2021;19:210-218.
Centers for Disease Control and Prevention. Guidelines for Infection Control in Eye Care Settings. 2022.
Chan BK, Abedon ST. Phage therapy for Staphylococcus aureus ocular infections: current progress and challenges. Phage. 2022;3(2):45-58.
Chang HY, Wang AG, Wang TY, et al. Topical linezolid 0.2% for methicillin-resistant Staphylococcus aureus ocular infections. Cornea. 2020;39(11):1389-1394.
Chong J, Lee J, Kim Y, et al. Rapid molecular detection of ocular pathogens using multiplex PCR in clinical settings. J Clin Microbiol. 2021;59(3):e02145-20.
Cronau H., Kankanala R.R., Mauger T. Diagnosis and management of red eye in primary care. Am. Fam. Physician. 2010;81:137–144. [PubMed] [Google Scholar]
Diekema DJ, Pfaller MA, Schmitz FJ, et al. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility. Clin Infect Dis. 2001;33(Suppl 3):S114-S123.
European Society of Clinical Microbiology and Infectious Diseases. Guidelines for the management of bacterial conjunctivitis. Clin Microbiol Infect. 2024;30(1):12-25.
Howden BP, Giulieri SG, Wong Fok Lung T, Baines SL, Sharkey LK, Lee JYH, Hachani A, Monk IR, Stinear TP. Staphylococcus aureus host interactions and adaptation. Nat Rev Microbiol. 2023 Jun;21(6):380-395. [PMC free article] [PubMed]
Kowalski RP, Romanowski EG, Shanks RMQ, et al. Evaluation of N-acetylcysteine as a biofilm dispersant in staphylococcal ocular infections. Invest Ophthalmol Vis Sci. 2019;60(8):2915-2922.
Lakhundi S, Zhang K. Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology. Clin Microbiol Rev. 2018 Oct;31(4) [PMC free article] [PubMed]
Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998 Aug 20;339(8):520-32. [PubMed]
Luchs JI, Miller D. Staphylococcal blepharoconjunctivitis and chronic ocular surface disease. Curr Opin Ophthalmol. 2019;30(4):287-293.
Otto M. Staphylococcal biofilms. Curr Top Microbiol Immunol. 2008;322:207-228.
Rønnevik A, Grevstad U, Sandvik T, et al. Clinical characteristics of bacterial conjunctivitis in adults: a prospective cohort study. Acta Ophthalmol. 2020;98(4):e512-e518.
Seng P, Drancourt M, Gouriet F, et al. Ongoing revolution in bacteriology: routine identification of bacteria by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Clin Infect Dis. 2009;49(4):543-551.
St. Leger A.J., Desai J.V., Drummond R.A., Kugadas A., Almaghrabi F., Silver P., Raychaudhuri K., Gadjeva M., Iwakura Y., Lionakis M.S., et al. An ocular commensal protects against corneal infection by driving an Interleukin-17 response from mucosal γδ T cells. Immunity. 2017;47:148–158.e5. doi: 10.1016/j.immuni.2017.06.014. [DOI] [PMC free article] [PubMed] [Google Scholar]
Sugita J., Yokoi N., Fullwood N.J., Quantock A.J., Takada Y., Nakamura Y., Kinoshita S. The detection of bacteria and bacterial biofilms in punctal plug holes. Cornea. 2001;20:362–365. doi: 10.1097/00003226-200105000-00005. [DOI] [PubMed] [Google Scholar]
Touaitia R, Mairi A, Ibrahim NA, Basher NS, Idres T, Touati A. Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms. Antibiotics (Basel). 2025 May 06;14(5) [PMC free article] [PubMed]
Wilcox MH, Tack KJ, Bouza E, et al. Comparative efficacy of topical fluoroquinolones in bacterial conjunctivitis: a meta-analysis. Clin Ther. 2018;40(6):987-1002.
Wong V.W.Y., Lai T.Y.Y., Chi S.C.C., Lam D.S.C. Pediatric Ocular surface infections: A 5-year review of demographics, clinical features, risk factors, microbiological results, and treatment. Cornea. 2011;30:995–1002. doi: 10.1097/ICO.0b013e31820770f4. [DOI] [PubMed] [Google Scholar]
World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report 2023. Geneva: WHO; 2023.
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