THE IMPORTANCE OF ANNEXIN‐A1 PROTEIN IN RHEUMATOID ARTHRITIS
Keywords:
Annexin-A1, biomarker, cancer, cell signaling and inflammation, formyl peptide receptor formyl peptide receptor (FPR), immune response, Granulocyte-macrophage colony-stimulating factor (GM-CSF).Abstract
Annexin-A1 has a clearly defined anti-inflammatory role in the innate immune system, however, its function in acquired immunity still remains a controversial issue. It has been established that the protein produced under the influence of this glucocorticoid is involved in various inflammatory conditions and cancers, as well as in T-cells of patients with autoimmune diseases. In addition, it has been established that the annexin-A1 receptor family, primarily signal-transmitting formyl peptides, plays a significant role in these diseases. In contrast, treatment with recombinant peptides annexin-A1 led to suppression of inflammatory processes in inflammatory models. This review focuses on what is currently known about annexin-A1 in health and disease and discusses the potential of this protein as a biomarker and therapeutic target.
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