THE EFFECTS OF 14-BENZOYLKARAKOLINE ON CONTRACTIVE ACTIVITY OF RAT AORTA SMOOTH MUSCLE CELLS
Abstract
It was investigated how 14-benzoylkarakoline affected the rat aortic smooth muscle cells' ability to contract. According to the results, rat aorta preparations that had been constricted by the beta-adrenergic receptor agonist phenylephrine are successfully relaxed by 14-O-BK. It can be deduced that the relaxant effect of the studied alkaloid is caused by the suppression of the transport of Ca2+ ions at the SR level in light of the fact that the contractions induced by this antagonist are primarily caused by the activation of the release of Ca2+ ions from the SR through IP3R.
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