OʻPKANING SURUNKALI OBSTRUKTIV KASALLIGIDA BUYRAKLAR DISFUNKSIYASINI ERTA ANIQLASHNING ZAMONAVIY BIOMARKERLARI: TIZIMLI TAHLILIY SHARH

Авторы

  • Ne’matov Sherzod Shavkat o‘g‘li magistr Toshkent Davlat Tibbiyot Universiteti Автор
  • Jabbarov Ozimbay Otaxanovich t.f.d., professor ilmiy rahbar Автор
  • Nazarova Nigina Otabekovna PhD Toshkent Davlat Tibbiyot Universiteti 2-son fakultet terapiya, nefrologiya va gemodializ kafedrasi Автор

Ключевые слова:

Oʻpkaning surunkali obstruktiv kasalligi, buyrak disfunksiyasi, erta diagnostika, biomarkerlar, Sistatin C, NGAL, KIM-1.

Аннотация

Oʻpkaning surunkali obstruktiv kasalligi (O‘SOK) tizimli yallig'lanish va gipoksiya bilan kechib, hayotiy muhim aʼzolar, xususan, buyraklar funksiyasining buzilishiga olib keladi. Anʼanaviy markerlar (zardob kreatinini, eGFR) buyraklar subklinik shikastlanishini erta bosqichlarda aniqlashda yetarli sezgirlikka ega emas.

Библиографические ссылки

World Health Organization (WHO). The top 10 causes of death. Global Health Estimates. WHO Guidelines; 2024.

Barnes PJ. Chronic obstructive pulmonary disease: a cardiovascular and systemic disease. European Respiratory Review. 2023;32(168):220-235.

Chen CY, Chen YC, et al. Impact of chronic kidney disease on mortality in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis. International Journal of COPD. 2022;17:1105-1118.

Soni SS, Wiznitzer MD, et al. Pulmo-renal crosstalk in the critically ill patient: Pathophysiology and clinical implications. Blood Purification. 2021;50(4):413-422.

Adeloye D, Song P, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2025: a systematic review and modelling analysis. The Lancet Respiratory Medicine. 2025;13(2):145-158.

Ronco C, Bellasi A, et al. Cardiorenal and Pulmorenal syndromes: The moving landscape of organ crosstalk. Journal of Nephrology. 2024;37(1):15-29.

Tang Y, Wang J, et al. Evaluation of Serum Cystatin C for early detection of renal impairment in patients with acute exacerbation of COPD. Respiratory Medicine. 2022;194:106-114.

Nasser M, Al-Hajjaj MS. Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as an early biomarker of kidney injury in chronic hypoxic respiratory failure. Journal of Clinical Medicine. 2023;12(9):3120.

Zhang X, Liu Y, et al. Kidney Injury Molecule-1 (KIM-1) and early tubular dysfunction in patients with stable and exacerbated COPD. International Urology and Nephrology. 2025;57(3):845-853.

Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global Strategy for the Diagnosis, Management, and Prevention of COPD: 2026 Report. GOLD Executive Summary; 2026.

Загрузки

Опубликован

2026-06-15

Как цитировать

Ne’matov, S., Jabbarov, O., & Nazarova, N. (2026). OʻPKANING SURUNKALI OBSTRUKTIV KASALLIGIDA BUYRAKLAR DISFUNKSIYASINI ERTA ANIQLASHNING ZAMONAVIY BIOMARKERLARI: TIZIMLI TAHLILIY SHARH. Центральноазиатский журнал академических исследований, 4(6 Part 2), 24-29. https://www.in-academy.uz/index.php/CAJAR/article/view/52264
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