DEVELOPMENT OF NEXT-GENERATION DRUGS AGAINST ANTIMICROBIAL RESISTANCE: MODERN STRATEGIES AND FUTURE PROSPECTS

Annotatsiya

Antimicrobial resistance (AMR) is one of the major global challenges that reduces the effectiveness of existing medicines in the treatment of infectious diseases and poses a serious threat to modern medicine. In particular, the spread of multidrug-resistant bacteria requires not only the development of new antibacterial drugs but also the creation of innovative strategies aimed at improving the efficacy of existing therapeutic agents. This article analyzes the major mechanisms of bacterial antimicrobial resistance, the identification of new molecular targets, the development of antibacterial compounds belonging to new chemical classes, antibiotic re-engineering, antimicrobial peptides, bacteriophage therapy, anti-virulence approaches, antibiofilm strategies, and combination therapy. The priority directions for the development of new medicines were also assessed based on the World Health Organization’s 2024 Bacterial Priority Pathogens List and data from the 2025 antibacterial clinical and preclinical pipeline. The literature review demonstrated that an effective pharmaceutical strategy against AMR should not be limited to the discovery of new antibiotics but should also encompass the development of agents with novel mechanisms of action, non-traditional biological therapeutics, drug combinations, and targeted drug-delivery technologies.