BAKTERIAL IRSIYATNING XROMOSOMADAN TASHQARI OMILLARI (PLAZMIDLAR, TRANSPAZONLAR, IS-FAKTORLAR, MO'TADIL FAGLAR), TIBBIYOTDAGI AHAMIYATI
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Bakterial irsiyat, plazmidlar, transpozonlar, IS-faktorlar, mo‘tadil faglar, ekstrakromosomal omillar, genetik mobil elementlar, antibiotik rezistentligi, virulentlik omillari, genetik almashinuv, konyugatsiya, transduktsiya, tibbiyot mikrobiologiyasi.Abstrak
Ushbu tezisda bakterial irsiyatning xromosomadan tashqari omillari — plazmidlar, transpozonlar, IS-faktorlar va moʻtadil faglarning tuzilishi, funksiyasi hamda genetik axborotni uzatishdagi roli yoritiladi.Bakteriyalarda ushbu ekstrakromosomal elementlar yuqori darajadagi moslashuvchanlikni ta’minlab, antibiotiklarga chidamlilik, virulentlik omillari, toksinlar sintezi va yangi metabolik xususiyatlarning shakllanishida muhim o‘rin tutadi. Shuningdek, bu omillarning tibbiyotdagi ahamiyati — antibiotik rezistentligi tarqalishi, klinik shtammlar evolyutsiyasi, infeksion kasalliklar patogenezidagi o‘rni va biotexnologik qo‘llanishi kabi jihatlar tahlil qilinadi. Tadqiqot ushbu genetik elementlarning patogenlikdagi roli va ularga qarshi samarali kurash strategiyalarini ishlab chiqishdagi ahamiyatini asoslaydi.
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