PENITSILAMIN VA 3D METALL KOMPLEKSLARINING KOORDINATSION VA BIOLOGIK XUSUSIYATLARI
Abstract
Penitsilamin – biologik faol aminokislota hosilasi bo‘lib, uning tarkibidagi –SH, –NH₂ va –COOH guruhlari turli 3d metall ionlari bilan mustahkam komplekslar hosil qilish imkonini beradi. Mazkur maqolada penitsilaminning Fe, Co, Ni, Cu va Zn ionlari bilan komplekslanish xususiyatlari, ularning barqarorligi hamda biologik ahamiyati keng yoritilgan. Tadqiqot davomida rentgenostruktura tahlili va turli spektroskopik metodlar yordamida komplekslarning tuzilishi o‘rganildi. Olingan natijalar penitsilamin–3d metall komplekslarining farmatsevtika va biomodellashtirish yo‘nalishlarida yuqori istiqbolga ega ekanini ko‘rsatdi.
References
Barik A.K., et al. Transition metal complexes of biologically active ligands: Synthesis, structure, and antimicrobial properties // Journal of Inorganic Biochemistry. 2007. Vol. 101. – P. 1115-1124.
Blower P.J. Metal chelating agents for therapy and diagnosis // Chemical Society Reviews. 1992. Vol. 21. – P. 93-102.
Hancock R.D. The Chelate, Macrocyclic and Cryptate Effects // Coordination Chemistry Reviews. 1992. Vol. 112. – P. 1-49.
Martell A.E., Motekaitis R.J. Determination and Use of Stability Constants. – New York: VCH Publishers, 1992. – P. 477.
Sigel H., Sigel A. (eds.). Metal Ions in Biological Systems: Interrelations Between Free Radicals and Metal Ions in Life Processes. – New York: Marcel Dekker, 1999. – P. 852 p.
Zeglis B.M., Pierre V.C., Barton J.K. Metallointercalators and metalloinsertors // Chemical Communications. 2007. – P. 4565-4579.
Readership
Published
Issue
Section
How to Cite
