DEVELOPMENT AND STABILITY EVALUATION OF AN ENHANCED DEXKETOPROFEN BIGEL FORMULATION

Аннотация:

Dexketoprofen, the active enantiomer of ketoprofen, is a potent nonsteroidal anti-inflammatory drug (NSAID) commonly used for the treatment of pain and inflammation. However, its photoinstability and thermal sensitivity limit the efficiency and shelf life of conventional topical gels. Recent advancements in pharmaceutical nanotechnology have demonstrated that bigels, biphasic systems composed of hydrogel and organogel phases, can enhance the stability, penetration, and controlled release of lipophilic and amphiphilic drugs. This study aims to develop a dexketoprofen-loaded bigel with improved physicochemical and microbiological stability, incorporating hydroxypropyl-β-cyclodextrin (HP-β-CD) as a solubilizer and stabilizing agent.