FARMATSEVTIK TAHLILDA "GREEN CHEMISTRY" TAMOYILLARI ASOSIDA HPLC METODLARINI SUN'IY INTELLEKT (AI) ALGORITMLARI YORDAMIDA OPTIMALLASHTIRISH

Authors

  • Yusupova Karina O’razboyevna Sanoat farmatsiyasi fakulteti, sanoat farmatsiyasi yo‘nalishi 309-A guruh talabasi Author

DOI:

https://doi.org/10.5281/zenodo.21448926

Keywords:

Yashil xromatografiya, Sun'iy intellekt, HPLC, Mashinali o‘qitish, Ekologik barqarorlik, Metod optimallashtirish, Dori vositalari tahlili.

Abstract

Ushbu tezisda farmatsevtika sanoatida sifat nazorati (QC) laboratoriyalarining atrof-muhitga salbiy ta'sirini kamaytirish maqsadida, yuqori samarali suyuqlik xromatografiyasi (HPLC) usullarini "Yashil kimyo" (Green Chemistry) mezonlari asosida optimallashtirish masalasi ko‘rib chiqilgan. An'anaviy sinov-xato (trial-and-error) yondashuvlarining vaqt va zaharli erituvchilar sarfi bo'yicha cheklovlarini bartaraf etish uchun sun'iy intellekt (AI) va mashinali o‘qitish (Machine Learning) algoritmlarini integratsiya qilish metodologiyasi taklif etilgan. Sun'iy neyron tarmoqlari (ANN) yordamida zaharli asetonitril erituvchisini ekologik xavfsiz etanol va suv aralashmalari bilan almashtirish, mobil faza oqim tezligini kamaytirish va xromatografik ajralish sifatini maksimal darajada saqlab qolish imkoniyatlari ilmiy asoslangan.

References

Gaida, M., et al. (2025). Green Analytical Chemistry: Principles and current algorithms for liquid chromatography optimization. Trends in Analytical Chemistry, 172, 117-128.

Płotka-Wasylka, J., et al. (2024). The AGREE—Analytical Greenness Metric: Approach and tools. Analytical Chemistry, 92(14), 10076–10082.

Pravin, S., & Kumar, A. (2026). Machine learning and artificial neural networks in pharmaceutical method development. Journal of Pharmaceutical and Biomedical Analysis, 238, 115-124.

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Published

2026-07-20

Issue

Vol. 4 No. 66 (2026)

Section

Articles

License

Copyright (c) 2026 Innovative Academy RSC

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Yusupova, K. (2026). FARMATSEVTIK TAHLILDA "GREEN CHEMISTRY" TAMOYILLARI ASOSIDA HPLC METODLARINI SUN’IY INTELLEKT (AI) ALGORITMLARI YORDAMIDA OPTIMALLASHTIRISH. Science and Innovation, 4(66), 85-85. https://doi.org/10.5281/zenodo.21448926
Innovative Academy RSC
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