SARATON METASTAZIDA GLIKOKIMYOVIY MODIFIKATSIYALARNING FIZIOLOGIK ROLI
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https://doi.org/10.5281/zenodo.20438639;
Glikokimyo, lektinlar, sialik kislota, metastaz fiziologiyasi, glikokaliks, adgeziya molekulalari.Abstrak
Saraton hujayralari yuzasidagi glikanlar tarkibining kimyoviy o‘zgarishi metastazlanish fiziologiyasining fundamental asosi hisoblanadi. Mazkur ishda hujayra membranasining hipersialillanishi immun tizimidan qochish va adgeziya mexanizmlarini boshqarishi tahlil qilinadi. O‘simta mikromuhitidagi lektin-uglevod interaksiyalari yangi turdagi target terapiya uchun asosiy nishon sifatida baholanadi.Iqtiboslar
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Mereiter, S., et al. (2019). Glycan Modifications in the Tumor Microenvironment. Frontiers in Oncology.
Schjoldager, K. T., et al. (2020). Human protein glycosylation pathways. Nature Reviews Molecular Cell Biology.
Zhou, J. Y. (2021). Chemical Probes for Sialic Acid Imaging. Chemical Science.
Fuster, M. M., & Esko, J. D. (2015). The sweet and sour of cancer progression. Nature Reviews Cancer.
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